Results 161 to 170 of about 4,908,147 (289)

Case Report: Successful telitacicept treatment for IgA nephropathy with stage 4 chronic kidney disease and acute renal failure. [PDF]

Front Immunol
Zeng F, Tan F, Liu D, Wang F.
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Acute Renal Failure Revealing Primary Renal Lymphoma With Bone Involvement: A Rare Case. [PDF]

Cureus
Laaribi I, Kachmar S, Berrichi S, Zaid I, Bkiyar H.   +4 more
europepmc   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Acute renal failure as the initial presentation of T-lymphoblastic lymphoma: A case report. [PDF]

Clin Nephrol Case Stud
Darwish N, Lightle A.
europepmc   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Fibrosis-4 index can predict improved renal function in acute heart failure with preserved ejection fraction

Background Improved renal function (IRF) observed in acute heart failure (AHF) is associated with poor prognosis. Since IRF is linked to renal congestion resulting from inadequate decongestion, predicting IRF could enhance management strategies.
デヤマ, ジュンタロウ, 佐藤, 明, 市川, 優真, 吉崎, 徹, Yoshizaki, Tohru, 24896, 90535551, クロキ, ケンジ, 中村, 貴光, 30456488, ヨコミチ, ヒロシ, 出山, 順太郎, Nakamura, Kazuto, ウエマツ, マナブ, 小林, 剛, 渡邉, 陽介, 00770174, 90746629, サトウ, アキラ, 植松, 学, 23375, 24621, 30528469, Ichikawa, Yuma, 40402052, 中村, 和人, 00622151, Horikoshi, Takeo, ホリコシ, タケオ, ナカムラ, カズト, Irie, Koken, コバヤシ, ツヨシ, Sato, Akira, Uematsu, Manabu, ヨシザキ, トオル, Yokomichi, Hiroshi, 50726940, 23542, Kuroki, Kenji, 23545, 24118, 黒木, 健志, 60377512, Watanabe, Yosuke, 20596879, 25120, 25122, 24594, ワタナベ, ヨウスケ, Nakamura, Takamitsu, 横道, 洋司, ナカムラ, タカミツ, イチカワ, ユウマ, Deyama, Juntarou, 24603, Kobayashi, Tsuyoshi, 23998, 堀越, 健生, 19418   +58 more
core   +1 more source

Impacts of hemoperfusion combined with continuous renal replacement therapy on renal function and immune function in patients with acute renal failure caused by poisoning. [PDF]

Front Med (Lausanne)
Fang H, Huang J, Fan S, Xu Y, Liu J.
europepmc   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Preclinical evaluation of a bioartificial kidney loaded with functional renal tubular cells in a Bama miniature pig model of acute renal failure. [PDF]

Burns Trauma
Xiao Y, Zhang C, Yang T, Huang Y, Wang X, Liu X, Li M, Cui S, Geng G, Li X, Li Q, Chen X.   +11 more
europepmc   +1 more source