Results 31 to 40 of about 233,117 (249)

Linear Association Between Hypoalbuminemia and Increased Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults

Critical Care Explorations, 2021
OBJECTIVES:. We hypothesized that low serum albumin would contribute to pulmonary edema formation, thereby independently increasing the risk of developing acute respiratory distress syndrome in critically ill patients. DESIGN:.
J. Brennan McNeil, MS, Karen E. Jackson, MD, Chunxue Wang, PhD, Edward D. Siew, MD, Andrew J. Vincz, AA, Ciara M. Shaver, MD, PhD, Julie A. Bastarache, MD, Lorraine B. Ware, MD   +7 more
doaj   +1 more source

Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation

Advanced Materials, EarlyView.
 Shell‐engineered poly(alkyl cyanoacrylate) microbubbles with tunable stiffness improve ultrasound imaging and therapy. Adjusting the length of the alkyl chain and the glass transition temperature maintains a narrow microbubble size distribution while enhancing drug loading, sonoporation and the acoustic response.
Roman A. Barmin, MirJavad Moosavifar, Elena Rama, Julia Blöck, Anne Rix, Vladislav S. Petrovskii, Rustam A. Gumerov, Jens Köhler, Michael Pohl, Céline Bastard, Stephan Rütten, Laura Charlton, Vu Ngoc Khiêm, Fabio Domenici, Thomas Lisson, Ekaterina Savina, Rui Zhang, Jasmin Baier, Susanne Koletnik, Vasileios Koutsos, Mikhail Itskov, Gaio Paradossi, Georg Schmitz, Tina Vermonden, Laura De Laporte, Robert Göstl, Andreas Herrmann, Igor I Potemkin, Fabian Kiessling, Twan Lammers, Roger M. Pallares   +30 more
wiley   +1 more source

A novel miRNA biomarker panel associated with mortality in pediatric patients with ARDS

Respiratory Research, 2021
We identified a novel microRNA biomarker panel consisting of 6 microRNAs predicting mortality in pediatric acute respiratory distress syndrome patients.
Lisa K. Lee, Mansoureh Eghbali, Anil Sapru   +2 more
doaj   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Use of esophageal balloon manometry in the management of pediatric acute respiratory distress syndrome

Respiratory Medicine Case Reports, 2020
There is paucity of literature regarding the use of esophageal balloon manometry in the management of Pediatric Acute Respiratory Distress Syndrome. We describe our first ever experience of successful usage of esophageal balloon pressure manometry in a ...
Elena Insley, Chad Pezzano, Shashikanth Ambati, Darren Lydon, Don Walker, Suzanne Barry   +5 more
doaj   +1 more source

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review)

Iranian Journal of Microbiology, 2021
Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), led to the ongoing global public health crisis.
Inna Krynytska, Mariya Marushchak, Inna Birchenko, Alina Dovgalyuk, Oleksandr Tokarskyy   +4 more
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