Results 71 to 80 of about 548,774 (332)

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Acute Respiratory Distress Syndrome Phenotypes [PDF]

Seminars in Respiratory and Critical Care Medicine, 2019
AbstractThe acute respiratory distress syndrome (ARDS) phenotype was first described over 50 years ago and since that time significant progress has been made in understanding the biologic processes underlying the syndrome. Despite this improved understanding, no pharmacologic therapies aimed at the underlying biology have been proven effective in ARDS.
John P, Reilly, Carolyn S, Calfee, Jason D, Christie   +2 more
openaire   +2 more sources

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review)

Iranian Journal of Microbiology, 2021
Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), led to the ongoing global public health crisis.
Inna Krynytska, Mariya Marushchak, Inna Birchenko, Alina Dovgalyuk, Oleksandr Tokarskyy   +4 more
doaj  

Formal guidelines: management of acute respiratory distress syndrome

Annals of Intensive Care, 2019
Fifteen recommendations and a therapeutic algorithm regarding the management of acute respiratory distress syndrome (ARDS) at the early phase in adults are proposed.
L. Papazian, C. Aubron, L. Brochard, J. Chiche, A. Combes, D. Dreyfuss, J. Forel, C. Guérin, S. Jaber, A. Mekontso-Dessap, A. Mercat, J. Richard, D. Roux, A. Vieillard-Baron, H. Faure   +14 more
semanticscholar   +1 more source

Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome.

New England Journal of Medicine, 2020
BACKGROUND In patients with acute respiratory distress syndrome (ARDS), the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network recommends a target partial pressure of arterial oxygen (Pao2) between 55 and 80 mm Hg.
L. Barrot, P. Asfar, F. Mauny, H. Winiszewski, Florent Montini, J. Badie, J. Quenot, S. Pili-Floury, B. Bouhemad, G. Louis, B. Souweine, O. Collange, J. Pottecher, B. Levy, M. Puyraveau, L. Vettoretti, J. Constantin, G. Capellier   +17 more
semanticscholar   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Successful application of airway pressure release ventilation in a child with severe acute respiratory distress syndrome induced by trauma: a case report

BMC Pulmonary Medicine
Background Trauma has been identified as one of the risk factors for acute respiratory distress syndrome. Respiratory support can be further complicated by comorbidities of trauma such as primary or secondary lung injury.
Jing Su, Xin Tie, Yao Chen, Tongjuan Zou, Wanhong Yin   +4 more
doaj   +1 more source

Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea

Journal of Korean medical science, 2020
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 not yet has established its treatment, but convalescent plasma has been expected to increase survival rates as in the case with other emerging viral infections.
J. Ahn, Yujin Sohn, Su Hwan Lee, Yunsuk Cho, J. Hyun, Y. Baek, S. Jeong, Jung Ho Kim, N. Ku, J. Yeom, J. Roh, M. Ahn, B. Chin, Young Sam Kim, Hyukmin Lee, D. Yong, Hyun Ok Kim, Sinyoung Kim, J. Choi   +18 more
semanticscholar   +1 more source

Acute respiratory distress syndrome

Indian Pediatrics, 2010
Acute respiratory distress syndrome (ARDS) is a common diagnosis among children admitted to pediatric intensive care units. This heterogeneous disorder has numerous pulmonary and non-pulmonary causes and is associated with a significant risk of mortality. Many supportive therapies exist for ARDS. SEARCH: Literature search was performed by using the key
openaire   +2 more sources