Results 81 to 90 of about 548,774 (332)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

High frequency ventilation in acute respiratory distress syndrome: a case report [PDF]

Einstein (São Paulo), 2005
Acute Respiratory Distress Syndrome is a common entity thataffects patients with serious conditions and has a high mortalityrate. It was published ten years ago that pulmonary protectiveventilation, with low tidal volumes and high respiratory frequencies,
Carolina Friedrich Amoretti, Nelson Hamerschlak, Lucília Santana Faria, Luciana Branco Haddad, Eduardo Juan Troster   +4 more
doaj  

Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study [PDF]

, 2022
Hui Chen, Qian Yu, Jianfeng Xie, Songqiao Liu, Chun Pan, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu, Yi Yang   +9 more
openalex   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Eosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication: a case report

Journal of Medical Case Reports, 2010
Introduction Legionella pneumonia can appear with different levels of severity and it can often present with complications such as acute respiratory distress syndrome.
Piro Roberto, Cavazza Alberto, Castagnetti Claudia, Menzella Francesco, Facciolongo Nicola, Carbonelli Cristiano, Zucchi Luigi   +6 more
doaj   +1 more source

Troponin T level in children with acute chest diseases and respiratory distress

Egyptian Journal of Chest Disease and Tuberculosis, 2020
Background Respiratory distress owing to pulmonary causes is the most common cause of visits to the pediatric emergency departments. Cardiac complications are reported to occur in acute respiratory tract diseases such as myocarditis, pericarditis, heart ...
Laila A.G Hegazy, Hania N Mossad, Nancy S Wahba, Sally R Ishak   +3 more
doaj   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Comparison of the efficacy of equivalent doses of dexamethasone, methylprednisolone, and hydrocortisone for treatment of COVID-19-related acute respiratory distress syndrome: a prospective three-arm randomized clinical trial [PDF]

, 2023
Abbas Taher, Marjan Lashkari, Fariba Keramat, Seyyed Hamid Hashemi, Ladan Sedighi, Jalal Poorolajal, Maryam Mehrpooya   +6 more
openalex   +1 more source

Guidelines on the management of acute respiratory distress syndrome

BMJ Open Respiratory Research, 2019
The Faculty of Intensive Care Medicine and Intensive Care Society Guideline Development Group have used GRADE methodology to make the following recommendations for the management of adult patients with acute respiratory distress syndrome (ARDS).
M. Griffiths, D. McAuley, G. Perkins, N. Barrett, B. Blackwood, Andrew J. Boyle, Nigel Chee, B. Connolly, P. Dark, S. Finney, Aemun Salam, J. Silversides, N. Tarmey, M. Wise, S. Baudouin   +14 more
semanticscholar   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source