Results 241 to 250 of about 881,734 (348)
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska+18 more
wiley +1 more source
High-frequency percussive ventilation in acute respiratory failure. [PDF]
Bruni A+9 more
europepmc +1 more source
Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen+7 more
wiley +1 more source
SELENON-related myopathy as a cause of acute respiratory failure in middle age: a case report. [PDF]
Risi B+13 more
europepmc +1 more source
HINT3 expression declines after myocardial ischemia‐reperfusion injury. In male mice, loss of HINT3 worsens cardiac injury and mitochondrial dysfunction, while its overexpression is protective. HINT3 binds the mitochondrial enzyme succinate dehydrogenase (SDHA) and prevents its deacetylation by histone deacetylase 1 (HDAC1), reducing succinate ...
Jiabin Yu+7 more
wiley +1 more source
Novel lung imaging techniques: new experimental insights in acute respiratory failure. [PDF]
Pellegrini M, Cereda M.
europepmc +1 more source
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu+13 more
wiley +1 more source