Results 21 to 30 of about 401,782 (243)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Noninvasive respiratory support in the emergency department: Controversies and state‐of‐the‐art recommendations

Journal of the American College of Emergency Physicians Open
Acute respiratory failure is a common reason for emergency department visits and hospital admissions. Diverse underlying physiologic abnormalities lead to unique aspects about the most common causes of acute respiratory failure: acute decompensated heart
Jarrod M. Mosier, Mark Tidswell, Henry E. Wang   +2 more
doaj   +1 more source

Reduced adiponectin levels in patients with COVID‐19 acute respiratory failure: A case‐control study

Physiological Reports, 2021
Hypoadiponectinemia is speculated to play a key role in the relationship between obesity and COVID‐19 respiratory failure. However, only one study has examined adiponectin levels in COVID‐19 patients, and none have investigated adiponectin levels ...
Sean M. Kearns, Katelyn W. Ahern, James T. Patrie, William B. Horton, Thurl E. Harris, Alexandra Kadl   +5 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Acute bilateral phrenic nerve neuropathy causing hypercapnic respiratory failure associated with checkpoint inhibitor immunotherapy

Respiratory Medicine Case Reports, 2021
We present two cases of acute hypercapnic respiratory failure due to diaphragmatic dysfunction secondary to bilateral phrenic nerve paralysis, in patients who were receiving immunotherapy for melanoma.
M. Srinivasan, A.M. Taylor, G.V. Long, G. Herkes, G.G. King   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparison of extracorporeal membrane oxygenation outcome for influenza-associated acute respiratory failure in Japan between 2009 and 2016

Journal of Intensive Care, 2018
Background Since the 2009 pandemic influenza, we have nationally established a committee of the extracorporeal membrane oxygenation (ECMO) project. This project involves adequate respiratory management for severe respiratory failure using ECMO.
Shinichiro Ohshimo, Nobuaki Shime, Satoshi Nakagawa, Osamu Nishida, Shinhiro Takeda, Committee of the Japan ECMO project   +5 more
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

ETIOLOGICAL AND CLINICO-PARACLINICAL CORRELATIONS IN CASE OF CHILDREN’S ACUTE RESPIRATORY FAILURE [PDF]

Romanian Journal of Pediatrics, 2017
Introduction. Acute respiratory failure presents very high morbidity and mortality among the pediatric patients, being one of the most frequent causes of recurring to the emergency services and of hospitalization. Material and method.
Iulia Armean, Cristina Oana Marginean, Lorena Elena Melit   +2 more
doaj   +1 more source