Results 171 to 180 of about 987,880 (303)

Regional variations and determinants of acute respiratory infection in Ethiopian children under five years: a multilevel analysis. [PDF]

Trop Med Health
Girmay AM, Getachew T, Zeru A, Ararso D, Achamyeleh H, Yirtaw TG, Taddele W, Dagne T, Zeweldemariam MS, Alemayehu S, Tesfaye H, Chekol DA, Gonfa G, Abride KB, Gebregiorgis WB, Leul Y, Getachew F, Molla G, Taddele T, Tadele A, Zeleke GT, Hailu M, Khashan AS, Tollera G.   +23 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Thrombotic Events and Stroke in the Year After COVID-19 or Other Acute Respiratory Infection. [PDF]

Emerg Infect Dis
Pratt CQ, Dalton AF, Koumans EH, Agedew A, Coronado F, Lundeen EA, Woodruff RC, Block JP, Weiner M, Cowell L, Arnold JD, Saydah S, PCORnet Network Partners.   +12 more
europepmc   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Saliva as a Reliable and Non-invasive Sample for Detecting Influenza A in Severe Acute Respiratory Infection Cases. [PDF]

Cureus
Takeuchi JS, Matsunaga N, Tsukada A, Iwamoto N, Fuwa N, Ichikawa T, Kato Y, Tomita Y, Kitagawa H, Yamato M, Aoyagi T, Hagiya H, Hase R, Hatakeyama S, Inaba T, Izumikawa K, Takesue Y, Kimura M, Ohmagari N.   +18 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

COVID-19 vaccination and mortality among coronary care patients with severe acute respiratory infection in Bangladesh: a prospective study (2021-2024). [PDF]

Lancet Reg Health Southeast Asia
Akhtar Z, Islam MA, Aleem MA, Shuvo TA, Hassan MZ, Asadullah, Rahman M, Rahman MZ, Hossain ME, Shirin T, Rahman M, Khan Jony MH, Monalisa, Sarker FR, Alam AN, Rubaid Anwar SNM, Rahman M, Jiamsakul A, Moa AM, Tan TC, Fröbert O, Chowdhury F, MacIntyre CR.   +22 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Seasonal dynamics and genetic diversity of human adenoviruses in patients with acute respiratory infection in Thailand, 2024. [PDF]

PLoS One
Puenpa J, Tantipraphat L, Aeemjinda R, Vichaiwattana P, Korkong S, Poovorawan Y.   +5 more
europepmc   +1 more source