Results 91 to 100 of about 1,385,174 (349)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The efficiency of interferon therapy for acute respiratory viral infections in young children

Детские инфекции (Москва), 2020
The problem of choosing an effective etiotropic treatment for acute respiratory viral infections in young children is one of the urgent in pediatrics.Materials and methods.
T. K. Chudakova, E. V. Mikhaylova
doaj   +1 more source

Viruses Associated with Acute Respiratory Infections [PDF]

BMJ, 1964
Since the discovery of the rhinoviruses and respiratory syncytial virus only a few surveys have been made on the incidence of infections by the different respiratory viruses in the general population and the frequency with which they cause respiratory disease (Hilleman et al., 1962 ; Conference on Newer Respiratory Disease Viruses, 1963 ; Higgins et al.
S K, CLARKE, B D, CORNER, D M, GAMBIER, J, MACRAE, D B, PEACOCK   +4 more
openaire   +2 more sources

Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland

European Respiratory Journal, 2018
While acute respiratory tract infections can trigger cardiovascular events, the differential effect of specific organisms is unknown. This is important to guide vaccine policy.
C. Warren-Gash, R. Blackburn, H. Whitaker, J. McMenamin, A. Hayward   +4 more
semanticscholar   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

A silent strain: the unseen burden of acute respiratory infections in children

Italian Journal of Pediatrics
The significant impact of acute respiratory tract infections on healthcare systems is well-documented, given their contribution to emergency department admissions, hospitalizations, and increased use of antibiotics and other medications. However, further
Riccardo Boracchini, Benedetta Canova, Pietro Ferrara, Luigi Cantarutti, Carlo Giaquinto, Costanza Di Chiara, Anna Cantarutti   +6 more
doaj   +1 more source

Issue of acute respiratory viral infection and influenza A (H^swin) in modern obstetrics [PDF]

Саратовский научно-медицинский журнал, 2012
Objective: To study the clinical features of the course and outcome of pregnancy accompanied by acute respiratory viral infections and influenza A (HN^win). Methods and materials.
Mikhailova E.V., Romanovskaya А.V., Salov I.A.   +2 more
doaj  

APPROACHES TO THE TREATMENT OF ACUTE RESPIRATORY INFECTIONS AND INFLUENZA DURING THE SEASONAL INCREASE IN THE INCIDENCE OF DISEASES

Вопросы современной педиатрии, 2015
Prevention and treatment of acute respiratory infections and influenza in children remain one of the major tasks of practical healthcare. Their importance increases with the beginning of the autumn-winter season.
L. L. Nisevich, K. S. Volkov, A. A. Alekseeva, A. Yu. Tomilova, V. A. Barannik, K. E. Efendieva   +5 more
doaj   +1 more source

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

Clinical Microbiology Reviews, 2018
Respiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory ...
C. Charlton, Esther Babady, C. Ginocchio, T. Hatchette, R. Jerris, Yan Li, M. Loeffelholz, Y. Mccarter, Melissa B. Miller, S. Novak-Weekley, A. Schuetz, Yi-Wei Tang, R. Widen, S. Drews   +13 more
semanticscholar   +1 more source