Results 51 to 60 of about 850,976 (303)

Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya [PDF]

, 2012
Background: Respiratory syncytial virus (RSV) reinfects individuals repeatedly. The extent to which this is a consequence of RSV antigenic diversity is unclear.
Alexander G. Mwihuri, Anderson, Cane, Cane, Cane, Cane, Cane, Charles J. Sande, Charles N. Agoti, Choi, Clayton O. Onyango, Collins, D. James Nokes, Falsey, Falsey, Glezen, Graham F. Medley, Gunson, Hall, Hall, Hall, Henderson, Johnson, Johnson, Melero, Mufson, Mufson, Nair, Nokes, Nokes, Ohuma, Okiro, Parveen, Patricia A. Cane, Peret, Peret, Posada, Sande, Scott, Sullender, Sullender, Tamura, Trento, Trento, Trento, Venter, Waris, White, Xia, Yamaguchi, Zlateva   +50 more
core   +1 more source

Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting [PDF]

, 2020
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in children worldwide and is a significant cause of hospital admissions in young children in England.
Kinyanjui, Timothy, Nokes, D. James, Pan-Ngum, Wirichada, Saralamba, Sompob, Taylor, Sylvia, White, Lisa J.   +5 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore. [PDF]

, 2017
To investigate the performance of laboratory methods and clinical case definitions in detecting the viral pathogens for acute respiratory infections (ARIs) from a prospective community cohort and hospital inpatients, nasopharyngeal swabs from cohort ...
AE Krafft, AM Caliendo, C Lim, C-C Li, CD Salgado, E Spackman, EAF Simões, F Freymuth, FG Hayden, FT Chew, FY Aoki, H Campe, J Gaillat, JA Fuller, JB Mahony, JY Noh, L Jiang, M Loeffelholz, RC She, RD Mistry, RK Zimmerman, RK Zimmerman, S Sadarangani, T Ferkol, TR Cate, V Peltola, V Sintchenko, VJ Lee   +27 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A silent strain: the unseen burden of acute respiratory infections in children

Italian Journal of Pediatrics
The significant impact of acute respiratory tract infections on healthcare systems is well-documented, given their contribution to emergency department admissions, hospitalizations, and increased use of antibiotics and other medications. However, further
Riccardo Boracchini, Benedetta Canova, Pietro Ferrara, Luigi Cantarutti, Carlo Giaquinto, Costanza Di Chiara, Anna Cantarutti   +6 more
doaj   +1 more source

Optimization of the therapy of ARVI and influenza in outpatient practice

Лечащий Врач
Background. Acute respiratory viral infections are a pathology that most often occurs in outpatient therapeutic practice (about 40 million cases per year). The term acute respiratory viral infection is a collective concept and denotes a group of diseases
D. S. Sukhanov, V. V. Basina, Yu. S. Alekseeva, E. V. Timofeev   +3 more
doaj   +1 more source

Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017 [PDF]

, 2018
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms.
Aghdassi, S., Alberg, T., Arendt, V., Arvaniti, K., Asensio, A., Berg, T. C., Berger-Carbonne, A., Borg, M. A., Bosnjak, Z., Budimir, A., Burns, K., Cairns, S., Cantero, M., Daniau, C., Debacker, M., Deptula, A., Dimina, E., Dobreva, E., Dragovac, G., Florentin, D., Gastmeier, P., Gibbons, C., Gudlaugsson, O., Hadjihannas, L., Hajdu, A., Hansen, S., Harrison, W., Hopkins, S., Hopmans, T., Hristova, R., Ivanov, I. N., Jindrak, V., Johnson, A., Karki, T., Kinross, P., Kontopidou, F., Korosec, A., Latour, K., Litvova, S., Lyytikainen, O., Markovic-Denic, L., Martin, P., McConaghy, M., Mitt, P., Monnet, D. L., Moro, M. L., Nedyalkov, M., Neves, I., Niculcea, A. S., Pacheco, P., Plachouras, D., Presterl, E., Quattrocolo, F., Reilly, J., Rydygier, L., Sartaj, M., Sarvikivi, E., Serban, R. I., Smid, E., Staniulyte, J., Stefkovicova, M., Strauss, R., Suetens, C., Vandael, E., Vilde, A., Weist, K., Zarb, P., Zingg, W., Zotti, C. M., Zupanc, T. L.   +69 more
core   +7 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Risk Factors of Acute Respiratory Infection in Children Aged 6-12 Years in Urban Areas: A Literature Review Study

Jurnal Ilmiah Kesehatan
One disease that affects school-aged children is Acute Respiratory Infections (ARI). Acute Respiratory Infections (ARI) can be caused by various causative agents, such as viruses, bacteria, or even fungi; air pollution from smoke or gas can also cause ...
Nikita Alia Rajebta, Shenia Rully Arvian, Winda Dwi Astuti, Chendy Yugu Tanca, Chahya Kharin Herbawani   +4 more
doaj   +1 more source