Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Arvi pattern in the Northwest federal district during the COVID-19 pandemic (2021–2022)
Инфекция и иммунитетAcute respiratory viral infections still remain a pressing health problem, causing both seasonal outbreaks and epidemics and global pandemics. The emergence of a new coronavirus infection has become a serious challenge, resulting in more than 776 million
A. A. Sharova +8 more
doaj +1 more source
Neonatal foal death due to infection with equine arteritis virus in Belgium [PDF]
, 2009 This case report describes a small outbreak of neonatal foal death in Belgium due to infection with equine arteritis virus (EAV). The outbreak started with one foal suffering from acute dyspnea four days after birth.
Chiers, Koen +6 more
core
Acute respiratory viral infections: Consensus on rational therapy
Consilium MedicumThere are diseases for which people turn to specific specialists, but there are also a number of ones that are treated by doctors of different specialties. Therapists, infectious disease specialists, otolaryngologists, and pulmonologists diagnose and treat acute respiratory viral infections. But the same specialists often have to deal with the outcomes
Andrey A. Zaytsev +3 more
openaire +2 more sources
Advanced Science, EarlyView.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
Forming statin response in patients with coronary heart disease in presence of acute respiratory viral infections by means of genetic markers [PDF]
, 2018 Г. С. Маль, Irina A. Gribovskaya
openalex +1 more source
Inhibition of adenovirus serotype 14 infection by octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- nucleosides in vitro. [PDF]
, 2018 On September 22, 2008, a physician on Prince of Wales Island, Alaska, notified the Alaska Department of Health and Social Services (ADHSS) of an unusually high number of adult patients with recently diagnosed pneumonia (n = 10), including three persons ...
Barnard, Dale L +8 more
core
Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond
Advanced Science, EarlyView.Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi +4 more
wiley +1 more source
Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection [PDF]
, 2015 Peter V. Dicpinigaitis +5 more
openalex +1 more source
Advanced Science, EarlyView.TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li +16 more
wiley +1 more source