Results 121 to 130 of about 795,614 (304)

Evaluation of toxicity studies of Sesbania grandiflora leaves extracts in Wistar albino rats

Journal of Applied Pharmaceutical Research
Objective: Sesbania grandiflora is a well-known medicinal plant belonging to the family Fabaceae, and it is used to treat several disorders. The current investigation aims to analyze the negative consequences of short and long-term administration of ...
Sharad Sharma, Bhupesh Chander Semwal, Avijit Mazumder   +2 more
doaj   +1 more source

Determination of Silver Binding to Natural Organic Matter Using Ion Selective Electrode [PDF]

, 2017
Natural organic matter (NOM) is considered an important factor in the protection of the aquatic environments; organic ligands can complex with metals, to decrease their toxicity and bioavailability. NOM is measured as dissolved organic carbon (DOC) in mg
Alshammari, Mona Muhawwis
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Acute toxicity studies of the South African medicinal plant Galenia africana

Toxicology Reports, 2018
Background: Medicinal plants are used by a large proportion of the global population as complementary and alternative medicines. However, little is known about their toxicity. G.
Tiza Ng’uni, Jeremy A. Klaasen, Burtram C. Fielding   +2 more
doaj   +1 more source

The impact of climate change on aquatic risk from agricultural pesticides in the US [PDF]

Agricultural pesticides have adverse impacts on water quality and aquatic species. These impacts are sensitive to climate because pest pressure and corresponding pesticide application rates vary with weather and climate conditions.
Nikolinka G. Koleva, Uwe a Schneider
core  

Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy. [PDF]

, 2018
PurposeRadiation dose escalation for prostate cancer improves biochemical control but is limited by toxicity. Magnetic resonance spectroscopic imaging (MRSI) can define dominant intraprostatic lesions (DIL).
Braunstein, Steve E, Chapman, Christopher H, Cunha, Adam, Gottschalk, Alexander R, Hsu, I-Chow, Kurhanewicz, John, Noworolski, Susan M, Pouliot, Jean, Roach, Mack Iii, Weinberg, Vivian   +9 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. Research of the acute toxicity of new compounds could prevent the development of compounds with high pharmacological activity, which exhibit undesirable pharmacological properties.
E. S. Pruglo, A. I. Panasenko, E. G. Knysh   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source