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Abstract Acute toxicity can be assessed based on data from appropriately conducted dose-escalation studies or short-duration dose-ranging studies. The principles of assessing acute and sub-acute toxicity are explained.
Phil Ambery +2 more
+4 more sources
Phil Ambery +2 more
+4 more sources
Acute toxicity studies with oxamyl
Fundamental and Applied Toxicology, 1986The acute toxicity of oxamyl, an insecticide and nematicide, has been evaluated to establish proper handling guides. The material is highly toxic when given as a single oral dose; its LD50 is in fasted rats 2.5 to 3.1 mg/kg, 2.3 to 3.3 mg/kg in fasted mice, and 7 mg/kg in guinea pigs. A beagle dog given 30 mg/kg died, while 15 mg/kg was not lethal.
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Hepcidin in acute iron toxicity
The American Journal of Emergency Medicine, 2009Hepcidin regulates extracellular iron concentration by inhibiting iron release from macrophages and preventing iron absorption in the intestine. Our objective was to evaluate the expression of hepcidin in the liver in acute iron poisoning in a rat model.Male Wistar rats were assigned to group 1, who received 750 mg/kg elemental iron (LD(50)) by gavage,
Michal, Toledano +9 more
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The acute toxicity of 2-benzylaminopyridine
Toxicology and Applied Pharmacology, 1976Abstract 2-Benzylaminopyridine (2-BAP) has been suspected of causing adverse reactions in man including headache, malaise, and skin rash. The purpose of this investigation was to determine and partially characterize the acute toxicity of 2-BAP. In mice the estimated LD50 of 2-BAP dissolved in equimolar HCl was 1187 mg/kg po and 224 mg/kg ip.
L C, Griffis, R B, Forney
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The acute toxicity of pesticides to rats
Toxicology and Applied Pharmacology, 1960Abstract 1. 1. LD50 values for 42 pesticides and 2 metabolites of DDT administered in a single dose by the oral or dermal route to Sherman strain adult rats have been determined. 2. 2. A comparison of laboratory results and use experience indicates that there is a much closer relationship between dermal LD50 values and the occurrence of ...
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Radiation therapy‐associated toxicity: Etiology, management, and prevention
Ca-A Cancer Journal for Clinicians, 2021Kyle Wang
exaly
Navigating financial toxicity in patients with cancer: A multidisciplinary management approach
Ca-A Cancer Journal for Clinicians, 2022Grace Li Smith +2 more
exaly
Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test
Aquatic Toxicology, 2022Yiming Xiong, Zhan-Fen Qin
exaly