In our real‐world study of 276 patients, rituximab and inebilizumab demonstrated comparable efficacy in the medium term but differed in their safety profiles, with a significantly higher incidence of infusion‐related reactions observed in the rituximab group.
Ying Cui +11 more
wiley +1 more source
Neuromyelitis Optica Spectrum Disorders (NMOSD); Diagnostic criteria (ORP-56) [PDF]
Neuromyelitis optica spectrum disorders (NMOSD) is an autoimmune astrocytopathy. The term NMOSD is used as an umbrella term that refers to Aquaporin-4 (IgG) positive NMO and some closely related clinical syndromes without AQP4-IgG. Core clinical features
Maryam Poursadeghfard
doaj
Predictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorders [PDF]
The detection of IgG aquaporin-4 antibodies in the serum of patients with Neuromyelitis optica (NMO) has dramatically improved the diagnosis of this disease and its distinction from multiple sclerosis.
Abril-Jaramillo, Javier +14 more
core +1 more source
Equine trypanosomiasis, a systematic review and meta‐analyses: Prevalence, morbidity and mortality
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Alexandra G. Raftery +5 more
wiley +1 more source
Acute Transverse Myelitis: Causes and Treatment
Clinical manifestations, laboratory findings, management, and course of nine children diagnosed with acute transverse myelitis (ATM) between 1993 and 1996 are reported from the Children’s University Hospital, Wurzburg, Germany.
J Gordon Millichap
doaj +1 more source
Case of a 35‐Year‐Old Man With Pain With Sneezing and Leg Weakness Causing Collapse
ABSTRACT This case details a 35‐year‐old man with no past medical history who presents with acute paraparesis and urinary retention in the setting of progressive paresthesias and weakness of his lower and upper extremities over several months. He was found to have longitudinally extensive transverse myelitis involving the cervical to mid‐thoracic cord ...
Joey Hsu +3 more
wiley +1 more source
Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis [PDF]
© 2014 Sridhar et al.; licensee BioMed Central Ltd.Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory condition of the central nervous system that is characterized by circulating anti-aquaporin-4 antibodies, transverse myelitis and ...
Chan, JFW, Sridhar, S, Yuen, KY
core +1 more source
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley +1 more source
Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis [PDF]
The term "acute transverse myelitis (ATM)” comprises various non-traumatic disorders that eventually can be associated with a focal myelopathy. Patients characteristically present with an acutely occurring paraparesis/plegia and require a comprehensive ...
Curt, Armin +3 more
core
Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin [PDF]
Background Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders.
Borisow, Nadja [u. v. m.] +3 more
core +1 more source

