Results 81 to 90 of about 4,491,218 (250)

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Viral Etiology and Symptoms of Acute Upper Respiratory Tract Infections in Children

, 2009
Aims: To determine viral causes of acute upper respiratory tract infections and clinical findings in children living in Istanbul ...
Unuvar, Emin, Kılıç, Ayşe, Sidal, Muejgan, Cakal, Bülent, Aslan, Seyhan Selvi, Badur, Selim, Oguz, Fatma, Toprak, Sadık, Yildiz, Ismail   +8 more
core  

Absence of dry season Plasmodium parasitaemia, but high rates of reported acute respiratory infection and diarrhoea in presschool-aged children in Kaédi, southern Mauritania [PDF]

, 2012
BACKGROUND: The epidemiology of malaria in the Senegal River Gorgol valley, southern Mauritania, requires particular attention in the face of ongoing and predicted environmental and climate changes. While 'malaria cases' are reported in health facilities
Koïta Mohamedou, Bâ Ousmane, Sy Ibrahima, Koïta, Mohamedou, Keïta Moussa, Moussa Keïta, Ibrahima Sy, Salem, C. B., Traoré, D., Bâ, Ousmane, Utzinger Jürg, Salem Cheikh B Ould Ahmed, Traoré Doulo, Guéladio Cissé, Ould, Ahmed, Mohamedou Koïta, Touray, Sunkaru, Jürg Utzinger, Bâ, H., Mirko S Winkler, Sy, I., Bâ Hampâté, Hampâté Bâ, Keïta, M., Touray, S., Cissé, G., Doulo Traoré, Utzinger, J., Touray Sunkaru, Cissé Guéladio, Ousmane Bâ, Cheikh B Ould Ahmed Salem, Koïta, M., Sunkaru Touray, Bâ, O., Winkler, M. S., Bâ, Hampâté, Salem, Cheikh B. Ould Ahmed, Winkler Mirko S, Sy I, Salem CB, Keïta M, Traoré D, Bâ H, Bâ O, Touray S, Utzinger J, Cissé G, Winkler MS, Koïta M   +49 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Acute upper respiratory infections admissions in England and Wales. [PDF]

Medicine (Baltimore), 2023
Al Rajeh AM, Naser AY, Siraj R, Alghamdi A, Alqahtani J, Aldabayan Y, Aldhahir A, Al Haykan A, Elmosaad YM.   +8 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Choice of therapy for coughing (spiral development)

Медицинский совет, 2019
Acute respiratory infections – the most common diseases in childhood, accompanied by cough. Treatment of cough is determined by the disease, the nature of sputum, the the general condition of the patient. The choice can be considered justified, depending
V. M. Deliagin
doaj   +1 more source

Deciphering Microbiota of Acute Upper Respiratory Infections: A Comparative Analysis of PCR and mNGS Methods for Lower Respiratory Trafficking Potential. [PDF]

Adv Respir Med, 2023
Almas S, Carpenter RE, Singh A, Rowan C, Tamrakar VK, Sharma R.   +5 more
europepmc   +1 more source