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Ru-catalyzed asymmetric transfer hydrogenation of α-acyl butyrolactone via dynamic kinetic resolution: Asymmetric synthesis of bis-THF alcohol intermediate of darunavir

Tetrahedron Letters, 2021
Abstract The Ru-catalyzed enantio- and diastereoselective dynamic kinetic resolution of α-(benzyloxy/benzoyloxy)acyl-γ-butyrolactones has been examined via transfer hydrogenation. Employing the in situ prepared (R,R)-Ru-FsDPEN catalyst, the transfer hydrogenation of using formic acid/triethylamine at rt gave the corresponding (S)-3-((S)-2-(benzyloxy ...
Ganesh V. More   +4 more
openaire   +1 more source

Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones

Chemical Reviews, 2017
Bin Mao   +2 more
exaly  

The Renaissance of α‐Methylene‐γ‐butyrolactones: New Synthetic Approaches

Angewandte Chemie - International Edition, 2009
Russell R A Kitson
exaly  

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