Results 271 to 280 of about 32,867 (333)

Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota

Journal of Gastroenterology and Hepatology, Volume 40, Issue 8, Page 2091-2103, August 2025.
ABSTRACT Background and Aim Metabolic dysfunction associated steatotic liver disease (MASLD) is the predominant cause of chronic liver disease, with dysregulation of bile acid (BA) metabolism and intestinal microbiota being intricately associated with MASLD progression.
Junjun Wang, Jiaqi Gao, Qingqing Zhang, Jingyi Lu, Yufei Yang, Xiaobo Cai, Hui Dong, Lungen Lu   +7 more
wiley   +1 more source

Complete pathway elucidation of echinacoside in Cistanche tubulosa and de novo biosynthesis of phenylethanoid glycosides. [PDF]

Nat Commun
Huang W, Yan Y, Tian W, Cui X, Wang Y, Song Y, Mo T, Xu X, Zhao S, Liu Y, Wang X, Wang J, Jiang Y, Li J, Shi SP, Liu X, Tu P.   +16 more
europepmc   +1 more source

The road less taken: Dihydroflavonol 4‐reductase inactivation and delphinidin anthocyanin loss underpins a natural intraspecific flower colour variation

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Visual cues are of critical importance for the attraction of animal pollinators, however, little is known about the molecular mechanisms underpinning intraspecific floral colour variation. Here, we combined comparative spectral analysis, targeted metabolite profiling, multi‐tissue transcriptomics, differential gene expression, sequence ...
Darren C. J. Wong, Zemin Wang, James Perkins, Xin Jin, Grace Emma Marsh, Emma Grace John, Rod Peakall   +6 more
wiley   +1 more source

Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer. [PDF]

Explor Drug Sci
Thyagarajan A, Sirhan Z, Sahu RP.
europepmc   +1 more source

Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation

New Phytologist, Volume 247, Issue 4, Page 1805-1825, August 2025.
Summary Cyanobacteria are major components of biofilms in light‐exposed environments, contributing to nutrient cycling, nitrogen fixation and global biogeochemical processes. Although nitrogen‐fixing cyanobacteria have been successfully used in biofertilization, the regulatory mechanisms underlying biofilm formation remain poorly understood.
Irene Olivan‐Muro, Jorge Guío, Germán Alonso‐Tolo, Emma Sevilla, María F. Fillat   +4 more
wiley   +1 more source

In vitro reconstitution reveals substrate selectivity of protein S-acyltransferases. [PDF]

J Biol Chem
Mondal T, Song J, Banerjee A.
europepmc   +1 more source

Engineering Gypsophila elegans hairy root cultures to produce endosomal escape‐enhancing saponins

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3068-3082, August 2025.
Summary The limited cytosolic delivery of DNA and protein‐based therapeutics due to endosomal entrapment reduces drug efficacy, increasing treatment costs and possible side effects in human and veterinary medicine as a consequence of higher administered dosages.
Elia Lacchini, Tongtong Qu, Tessa Moses, Alexander N. Volkov, Alain Goossens   +4 more
wiley   +1 more source

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

Angewandte Chemie, Volume 137, Issue 31, July 28, 2025.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Jonas Fiedler, Leo Dumjahn, Mie Ishida‐Ito, Felix Trottmann, Keishi Ishida, Christian Hertweck   +5 more
wiley   +2 more sources

Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect. [PDF]

Molecules
Wang T, Rangji C, Liu W, Ma J, Zhou R, Leng L, Zhang Y.   +6 more
europepmc   +1 more source

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

Experimental Physiology, Volume 110, Issue 8, Page 1071-1086, 1 August 2025.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood, Nicola Morrice, Dawn Thompson, Sara Milanizadeh, Sophie Wilson, Philip D. Whitfield, George D. Mcilroy, Justin J. Rochford, Nimesh Mody   +8 more
wiley   +1 more source