Results 291 to 300 of about 24,285 (335)

Lactylation in cancer: Advances and opportunities for treatment resistance

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Aberrant lactylation plays a crucial role in the development of resistance to chemotherapy, immunotherapy, targeted therapy, and radiotherapy. Strategies to overcome this resistance include the inhibition of key glycolytic enzymes, targeting lactate transporters, synergistic therapeutic approaches, and the inhibition of specific site.
Keke Xu, Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaomeng Dai, Xuanwen Bao, Xiaoyan Chen, Luanluan Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu   +10 more
wiley   +1 more source

Leaf oil under stress: divergent lipid synthesis and stabilization strategies in tobacco. [PDF]

Plant Physiol
Shakir S.
europepmc   +1 more source

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, Volume 4, Issue 5, October 2025.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis

Banducci-Karp A, Brixton S, Shah PNM, Li M, Fisher G, Riepsaame J, Dhaliwal R, Holden KL, Drydale E, Bancroft J, Melia CE, Malavige GN, Sanyal S.   +12 more
europepmc   +1 more source

Mechanisms of Osteoblast‐Like Cells and Bacterial Responses to Copper in Titanium‐Copper Alloys

Journal of Biomedical Materials Research Part A, Volume 113, Issue 10, October 2025.
ABSTRACT Titanium‐copper (Ti‐Cu) alloys are gaining attention for their dual functionality in promoting osteogenesis while providing antimicrobial protection, making them ideal candidates for dental and orthopedic implants. Copper's ability to enhance bone cell activity and inhibit bacterial growth could help address two critical challenges: successful
Javeria Khalid, Abish S. Stephen, Simon C. F. Rawlinson, Robert P. Allaker   +3 more
wiley   +1 more source

Microbial cell factory for butyl butyrate production: Knowledges and perspectives. [PDF]

Microb Biotechnol
Guo X, Ding Y, Chen Y, Fu H, Wang J.
europepmc   +1 more source

The Lrs14‐Like AbfR1 Homolog From Metallosphaera sedula Is a Nucleoid‐Organizing Protein

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Nucleoid organization in Crenarchaeota involves diverse small DNA‐binding proteins. The Lrs14‐type protein AbfR1 from Metallosphaera sedula binds nonsequence specifically across the genome and induces DNA condensation. These findings suggest a structural role for AbfR1Ms in chromatin architecture, functionally resembling bacterial nucleoid‐associated ...
Veerke De Kock, Ronnie Willaert, Yannick Gansemans, Filip Van Nieuwerburgh, Rani Baes, Eveline Peeters   +5 more
wiley   +1 more source

Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism. [PDF]

Philos Trans R Soc Lond B Biol Sci
Ji W, Osbourn A, Liu Z.
europepmc   +1 more source

MYRF gene mutation leading to coronary artery anomaly combined with 46,XY sex development disorder, a case report and literature review. [PDF]

BMC Pediatr
Ding J, Lv Z, Zhen Z, Gai Y, Xiao Y.
europepmc   +1 more source

Association of <i>LPCAT1</i>*rs9728 Variant with Reduced Susceptibility to Neonatal Respiratory Distress Syndrome. [PDF]

Biomedicines
Dorgham S, Yahia S, Shahin D, Eita AM, Toraih EA, Elshazli RM.   +5 more
europepmc   +1 more source