Results 301 to 310 of about 32,557 (330)
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Serine carboxypeptidase-like acyltransferases
Phytochemistry, 2004In plant secondary metabolism, an alternative pathway of ester formation is facilitated by acyltransferases accepting 1-O-beta-acetal esters (1-O-beta-glucose esters) as acyl donors instead of coenzyme A thioesters. Molecular data indicate homology of these transferases with hydrolases of the serine carboxypeptidase type defining them as serine ...
Dieter Strack, Carsten Milkowski
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Mechanism and function of DHHC S-acyltransferases
Biochemical Society Transactions, 2013Protein S-palmitoylation is a reversible post-translational modification of proteins with fatty acids. In the last 5 years, improved proteomic methods have increased the number of proteins identified as substrates for palmitoylation from tens to hundreds.
Benjamin C. Jennings, Maurine E. Linder
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[11] Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine
1992Publisher Summary The acylation of diacylglycerol catalyzed by the diacylglycerol acyltransferase is the only enzyme reaction unique to triacylglycerol synthesis. This reaction lies at the diacylglycerol branch point of phosphatidylcholine, phosphatidylethanolamine, and triacylglycerol synthesis.
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Inhibition of acyltransferase in lymphocytes by concanavalin A
Biochimica et Biophysica Acta (BBA) - General Subjects, 1980The effects of concanavalin A and succinylated concanavalin A on the transformation of mouse splenic lymphocytes, and on early biochemical events in the transformation, were compared. 1. The transformation of lymphocytes is biphasic with respect to concanavalin A concentration with optimal activation at about 1 microgram/ml.
Alan Mellors, Paul Dobson
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1983
Publisher Summary This chapter focuses on carnitine acyltransferases. The carnitine enzyme with a large acyl transfer capacity for acetyl residues is called “carnitine acetyltransferase” (CAT), whereas the enzyme, which has a high transfer capacity for palmityl residues, is named “carnitine palmityltransferase” (CPT).
Loran L. Bieber, Shawn Farrell
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Publisher Summary This chapter focuses on carnitine acyltransferases. The carnitine enzyme with a large acyl transfer capacity for acetyl residues is called “carnitine acetyltransferase” (CAT), whereas the enzyme, which has a high transfer capacity for palmityl residues, is named “carnitine palmityltransferase” (CPT).
Loran L. Bieber, Shawn Farrell
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DHHC2 is a proteinS-acyltransferase for Lck
Molecular Membrane Biology, 2011Lck is a non-receptor tyrosine kinase of the Src family that is essential for T cell activation. Dual N-terminal acylation of Lck with myristate (N-acylation) and palmitate (S-acylation) is essential for its membrane association and function. Reversible S-acylation of Lck is observed in vivo and may function as a control mechanism. Here we identify the
Zeidman, Ruth +5 more
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Acyltransferases and Triacylglycerols
2018Glycerolipids, by far the largest group of plant lipids, are structurally based on glycerol. This group includes glycodiacylglycerols, phospholipids, and acylglycerols such as triacylglycerol. The properties of the triacylglycerols depend on the fatty acids esterified with each of the three hydroxyl groups of glycerol.
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A protein cofactor of lecithin:Cholesterol acyltransferase
Biochemical and Biophysical Research Communications, 1972Abstract The effect of proteins isolated from human high density lipoprotein on cholesterol esterification by purified lecithin:cholesterol acyltransferase in the presence of dispersed lipids was studied. One of the major proteins present gave a maximal rate of esterification similar to that found with the native lipoprotein.
V.G. Shore +5 more
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Inhibitors of Acyl CoA:Cholesterol Acyltransferase
Journal of Medicinal Chemistry, 1996Conformational restriction of previously disclosed acyclic (diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4-Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 microM in an in vitro rat hepatic microsomal ...
Rosy Sher +9 more
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A review on lecithin:cholesterol acyltransferase deficiency
Clinical Biochemistry, 2015Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C). Genetic disorders of LCAT are associated with lipoprotein abnormalities including low levels of HDL-C and presence of lipoprotein X, and clinical features mainly corneal ...
Min Li, Ramesh Saeedi, Jiri Frohlich
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