Results 21 to 30 of about 283,905 (249)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Performance Analysis of a Novel TCP Protocol Algorithm Adapted to Wireless Networks
Future Internet, 2020 As telecommunication systems evolve towards new-generation architectures, likewise, new protocols are created in order to improve efficiency. One of these protocols is Transmission Control Protocol (TCP), which controls the transmission bit rate in ...
Gonzalo Olmedo +3 more
doaj +1 more source
Internet Policy Review, 2022 There is no one set definition for the phrase “ad hoc networks”. The term refers to the ability for members of a network to establish a network connection between devices.
Kelsie Nabben, Ellie Rennie
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
SABERES DOS PROFESSORES BACHARÉIS E DOCÊNCIA NA EDUCAÇÃO SUPERIOR
Educação em FocoFundamentado na psicologia sócio-histórica, este artigo apresenta um excerto de uma pesquisa de doutoramento realizada com professores bacharéis economistas de duas instituições de educação superior privadas do interior do estado de São Paulo ...
Juliana Sampaio Mori +1 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
How to make ad hoc proof automation less ad hoc [PDF]
Journal of Functional Programming, 2011 AbstractMost interactive theorem provers provide support for some form of user-customizable proof automation. In a number of popular systems, such as Coq and Isabelle, this automation is achieved primarily throughtactics, which are programmed in a separate language from that of the prover's base logic. While tactics are clearly useful in practice, they
Gonthier, G. +3 more
openaire +4 more sources