Results 61 to 70 of about 444,119 (297)
Human resource allocation management in multiple projects using sociometric techniques [PDF]
, 2012 This article describes a new application of key psychological concepts in the area of Sociometry for the selection of workers within organizations in which projects are developed. The project manager can use a new procedure to determine which individuals
Aldefer +43 more
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Distinguishability in Entropy Calculations: Chemical Reactions, Conformational and Residual Entropy
Entropy, 2011 By analyzing different examples of practical entropy calculations and using concepts such as conformational and residual entropies, I show herein that experimental calorimetric entropies of single molecules can be theoretically reproduced considering ...
Ernesto Suárez
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Discourse Informativeness in Alzheimer's Disease and Mild Cognitive Impairment
Listy klinicke logopedieIn recent years, the assessment of the language abilities of persons with cognitive deficits has focused on discourse assessment. Specifically, the assessment of informativeness proves to be an effective diagnostic tool.
Viktória Čiernik Kevická +2 more
doaj +1 more source
An Offline Roadside Unit ON-OFF Scheduling Algorithm for Energy Efficiency of Ad Hoc Networks
IEEE Access, 2018 This paper considers the off-line roadside unit (RSU) ON/OFF scheduling problem in a sparse vehicular ad hoc network (VANET). We formulate the problem as a mixed integer non-linear programming problem and propose a heuristic scheduling algorithm called ...
Lei Zhang, Yu Wang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Ibérica, 2020 This paper examines the role of the adjective “unique” in car manufacturers’ websites. The presence of adjectives is generally acknowledged to be a significant feature of advertising texts; however, analyses often focus on issues relating to the ...
Marisa Díez Arroyo
doaj
E3S Web of Conferences, 2018 After the disastrous flood events of June 2013 in the German Elbe and Danube catchments, the German government together with the federal states decided on the joint elaboration of a nationwide flood protection programme (NHWSP, 2015-2027+).
Schuh Carina, Hatz Marcus
doaj +1 more source