Results 61 to 70 of about 22,573 (262)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

De la Homofilia a la Cohesión social y viceversa

REDES: Revista Hispana para el Análisis de Redes Sociales, 2011
Este artículo tiene cuatro objetivos articulados. Primero, presentar los contenidos con que, en la literatura ad hoc, se suelen identificar y analizar la Cohesión social y la Homofilia.
Carlos Lozares, Joan Miquel Verd
doaj   +3 more sources

Adapting Ad Hoc Concepts in Screen Productions

SKASE Journal of Translation and Interpretation
This paper examines how ad hoc concepts are rendered in the English subtitles of colloquial Jordanian Arabic in the Netflix film The Alleys (2021). Ad hoc concepts, shaped through narrowing, broadening, or both, result from pragmatic modifications of lexical items.
Ali, Sukayna, Jarrah, Marwan, Al-Adwan, Amer   +2 more
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Forms and types of recognition in modern international law

RUDN Journal of Law, 2011
On the basis of the analysis of various concepts of a recognition and consideration of the mechanism of action of this institute of recognition in time, generalizations of modern practice the author comes to the conclusion that separate («intermediate ...
Kh M Dzhantaev
doaj  

Semantic and grammatical features of the languages of entrepreneurship practices [PDF]

SHS Web of Conferences
Social phenomena in the first stages of their comprehension are investigated using general scientific methods, which are methods of the natural sciences.
Baryshev Aleksey, Kashpur Valeriya
doaj   +1 more source

Ad hoc Cloud Computing: From Concept to Realization

, 2015
This paper presents the first complete, integrated and end-to-end solution for ad hoc cloud computing environments. Ad hoc clouds harvest resources from existing sporadically available, non-exclusive (i.e. primarily used for some other purpose) and unreliable infrastructures.
McGilvary, Gary Andrew, Barker, Adam, Atkinson, Malcolm   +2 more
openaire   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source