Results 61 to 70 of about 445,276 (292)

Ad hoc concepts, affective attitude and epistemic stance

Pragmatics & Cognition, 2022
AbstractIn relevance-theoretic pragmatics thelower-levelorfirst-order explicatureis a propositional form resulting from a series of inferential developments of the logical form. It amounts to the message the speaker communicates explicitly. Thehigher-levelorsecond-order explicatureis a description of the speech act that the speaker performs, her ...
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Toward Highly Dependable Power-Aware Mobile Ad Hoc Network–Survivability Evaluation Framework

IEEE Access, 2015
Network survivability is an attribute that network is continually available even if a communication failure occurs, and is regarded as one of the most important concepts to design dependable computer networks.
Zhipeng Yi, Tadashi Dohi
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Distinguishability in Entropy Calculations: Chemical Reactions, Conformational and Residual Entropy

Entropy, 2011
By analyzing different examples of practical entropy calculations and using concepts such as conformational and residual entropies, I show herein that experimental calorimetric entropies of single molecules can be theoretically reproduced considering ...
Ernesto Suárez
doaj   +1 more source

Strategies for Searching Video Content with Text Queries or Video Examples [PDF]

, 2016
The large number of user-generated videos uploaded on to the Internet everyday has led to many commercial video search engines, which mainly rely on text metadata for search. However, metadata is often lacking for user-generated videos, thus these videos
Chang, Xiaojun, Du, Xingzhong, Gan, Chuang, Hauptmann, Alexander G., Jiang, Lu, Lan, Zhenzhong, Li, Huan, Li, Xuanchong, Lin, Ming, Ma, Zhigang, Mao, Zexi, Meng, Deyu, Xu, Shicheng, Xu, Zhongwen, Yang, Yi, Yu, Shoou-I   +15 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Conceptual Metaphor Theory and Classical Theory: Affinities Rather than Divergences [PDF]

, 2016
Conceptual Metaphor Theory makes some strong claims against so-called Classical Theory which spans the accounts of metaphors from Aristotle to Davidson.
Mácha, Jakub
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Discourse Informativeness in Alzheimer's Disease and Mild Cognitive Impairment

Listy klinicke logopedie
In recent years, the assessment of the language abilities of persons with cognitive deficits has focused on discourse assessment. Specifically, the assessment of informativeness proves to be an effective diagnostic tool.
Viktória Čiernik Kevická, Petra Brandoburová, Jana Marková   +2 more
doaj   +1 more source