Results 31 to 40 of about 51,572 (261)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Mobile ad-hoc networks: MANET [PDF]

open access: yesTrendovi u Poslovanju, 2018
Currently in 2018, 7.6 billion people are in the world, and 8.6 billion mobile devices. As mobile phones have completely changed the meaning of the term to be available, a similar change in the wait and laptops users is, so it is only a matter of time ...
Mikarić Bratislav   +2 more
doaj  

IDHOCNET: A Novel ID Centric Architecture for Ad Hoc Networks

open access: yesJournal of Computer Networks and Communications, 2016
Ad hoc networks lack support of infrastructure and operate in a shared bandwidth wireless environment. Presently, such networks have been realized by various adaptations in Internet Protocol (IP) architecture which was developed for infrastructure ...
Shahrukh Khalid   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Infrastructured ad hoc networks

open access: yesProceedings. International Conference on Parallel Processing Workshop, 2003
In traditional ad hoc networks, all nodes are considered equal and take equal part in the routing and forwarding of packets. We believe that this may not always be desirable. Rather, some nodes may be equipped with virtually unlimited power supplies, while others have to rely on battery power Thus, we propose the creation of "infrastructured" ad hoc ...
Lindgren, Anders, Schelén, Olov
openaire   +3 more sources

MIMO Communications in Ad Hoc Networks [PDF]

open access: yes2005 IEEE 61st Vehicular Technology Conference, 2005
We consider MIMO (multiple-input multiple output) communications in an ad hoc network with K simultaneous communicating transceiver pairs. In particular, we compare channelized MIMO transmission and the MIMO interference transmission using the inherent multiplexing gain of multiple transmit/receive antennas.
Chen, Biao, Gans, Michael J.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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