Results 171 to 180 of about 1,453,555 (276)

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

<i>In silico</i> investigation of <i>Aloe vera</i> phytoconstituents targeting key proteins involved in atopic dermatitis progression. [PDF]

BioTechnologia (Pozn)
El Bouamri L, Bouribab A, Bouachrine M, Chtita S.   +3 more
europepmc   +1 more source

Quenching Photo‐Induced Free Radicals Endows Superomniphobic Atmospheric Water Harvesting Hydrogels With UV Resistance for Durable Bifacial Photovoltaic Cooling

Advanced Science, EarlyView.
A hygroscopic hydrogel layer functionalized with fullerene C60 tackles heat and dust challenges in bifacial photovoltaics (PV) panels. It resists soiling and photo‐aging, maintains high transparency, absorbs water vapor from the air during the night, and delivers strong evaporative cooling power during daytime, significantly lowering PV panel ...
Xiaoqi Zhou, Chengyu Yang, Rongrong Ma, Kun Zhang, Liyin Liu, Bo Wu, Renyuan Li   +6 more
wiley   +1 more source

Skin Barrier-Informed Topical and Transdermal Drug Delivery: Excipient-Driven Strategies, Vehicle Transformation, and Translational Challenges. [PDF]

Pharmaceutics
Sapkota B, Phuyal S, Bamjan AD, Cho SS, Shim JH, Park JW, Subedi L.   +6 more
europepmc   +1 more source

1,2-propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia. [PDF]

Animal Model Exp Med
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Li X, Chen Y, Xiao X, Xu G.
europepmc   +2 more sources

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer's Therapy. [PDF]

PLoS One
Asghar S, Khan MU, Jawaid T, Rehman R, Shafi A, Alzahrani AR, Rehman ZU, Khan A.   +7 more
europepmc   +1 more source

Gel‐Free Capture of Microvolt‐Level Neural Signatures Via a 3D Monolithic Carbon Fiber Dry Electrode

Advanced Science, EarlyView.
A compressible carbon fiber/PEDOT:PSS electrode enables gel‐free contact at hairy scalp sites. Its conductive porous framework supports low interfacial impedance and retains contact performance after repeated mechanical and sweat‐related challenges.
Haoxuan Sun, Nikolay Novitskiy, Dongwook Jang, Yixiang Liu, Shaoqi Pan, Ting Huang, Yitong Li, Huisi Yang, Leonardo Nicholas Adi Wijaya, Md Masruck Alam, Patrick CM Wong, Zhaoli Gao   +11 more
wiley   +1 more source

Delgocitinib in dermatology: a topical pan-JAK inhibitor for chronic hand eczema and atopic dermatitis. [PDF]

Ann Med Surg (Lond)
Haider E, Tanveer L, Usman Iqbal M, Taj J, Tague C.   +4 more
europepmc   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source