Results 11 to 20 of about 14,942 (62)

Management of Mechanical Ventilation in Decompensated Heart Failure. [PDF]

open access: yes, 2016
Mechanical ventilation (MV) is a life-saving intervention for respiratory failure, including decompensated congestive heart failure. MV can reduce ventricular preload and afterload, decrease extra-vascular lung water, and decrease the work of breathing ...
Adams, Jason Y   +4 more
core   +4 more sources

A case report of Adams-Stokes syndrome: Complete atrio-ventricular block manifested as cardiogenic syncope [PDF]

open access: yesHalo 194
Introduction/objective: Syncope is a sudden and transient loss of consciousness caused by brain tissue hypoperfusion. The Adams-Stokes Syndrome (ASS) is a type of arrhythmia that manifests as cardiogenic syncope.
Janković Tamara, Đorđević Stefan
doaj   +1 more source

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

open access: yes, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Aasland   +65 more
core   +4 more sources

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

open access: yes, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]

open access: yes, 2018
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre   +68 more
core   +3 more sources

Constructing dementia and dementia care: daily practices in a day care setting [PDF]

open access: yes, 2005
• Summary:This article explores the ways in which dementia can be constructed and maintained by the actions, and received ideas concerning dementia, of social care staff practising in a local authority day care setting in the UK.The article is set ...
Parker, Jonathan
core   +1 more source

Heart transplantation in a patient with primary malignant tumor

open access: yesВестник трансплантологии и искусственных органов, 2019
The article looks at a clinical case of a 31-year-old female with signs of paroxysmal ventricular tachycardia and Morgagni–Adams–Stokes syndrome. In April 2014, electrophysiological examination revealed a source of ventricular tachycardia localized in ...
E. E. Kliver   +4 more
doaj   +1 more source

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]

open access: yes, 2015
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina   +12 more
core   +2 more sources

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

open access: yes, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami   +302 more
core   +1 more source

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases [PDF]

open access: yes, 2004
Bloom's syndrome (BS), a disorder associated with genomic instability and cancer predisposition, results from defects in the Bloom's helicase (BLM) protein.
Dunphy, William G.   +3 more
core   +3 more sources

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