Results 21 to 30 of about 17,079 (213)

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig, Eamonn Kelly, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Alex C. Conner, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, Chandy George, Steve A. N. Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +72 more
wiley   +1 more source

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]

, 2018
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre, Anselme, Aravind, Beales, Bergen, Berger, Berson, Billaud, Burnside, Burridge, Cahalan, Carroll, Chapman, Cossart, Ferreira, Ferreira, Fuchs, Habas, He, Hildebrandt, Hogan, Imanishi, Jacobson, Johnson, Kaibuchi, Katsanis, Kaykas, Kelley, Khaliq, Khanna, Khanna, Kroes, Lewis, Li, Li, Li, MacDonald, MacDonald, Meyer, Mitchell, Nelson, Nishina, Nusse, Prevarskaya, Putney, Ridley, Roepman, Rosado, Rüther, Rüther, Sage, Schermer, Schneider-Maunoury, Shu, Stainier, Tolwinski, Torban, Vaudin, Vervoort, Vesque, Wallingford, Wittinghofer, Wolfrum, Wright, Wright, Wright, Wright, Wright, Zrenner   +68 more
core   +3 more sources

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases [PDF]

, 2004
Bloom's syndrome (BS), a disorder associated with genomic instability and cancer predisposition, results from defects in the Bloom's helicase (BLM) protein.
Dunphy, William G., Kim, Soo-Mi, Lee, Joon, Li, Wenhui   +3 more
core   +3 more sources

Heart transplantation in a patient with primary malignant tumor

Вестник трансплантологии и искусственных органов, 2019
The article looks at a clinical case of a 31-year-old female with signs of paroxysmal ventricular tachycardia and Morgagni–Adams–Stokes syndrome. In April 2014, electrophysiological examination revealed a source of ventricular tachycardia localized in ...
E. E. Kliver, I. S. Murashov, A. M. Volkov, E. N. Kliver, D. V. Doronin   +4 more
doaj   +1 more source

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami, Adams, Adelman, Aguero-Torres, Ahima, Ahren, Akomolafe, Antuna-Puente, Arribas, Arvanitakis, Arvanitakis, Astrup, Bannon, Baran, Barber, Bartus, Barzilai, Baumbach, Baumbach, Baumbach, Behrendt, Bellinger, Berlett, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bjorntorp, Blander, Boden, Bolton, Bordone, Bordone, Brandes, Braun, Bravo, Broughton, Bruce-Keller, Buettner, Bugalho, Bullo, Cai, Calabrese, Calabrese, Calabrese, Calabrese, Calabrese, Carlsson, Carr, Cecarini, Cefalu, Cefalu, Chen, Chen, Chen, Clark, Clayton, Clayton, Comfort, Coon, Coyle, Coyle, Craft, Craft, Curb, Damjanovic, De Feo, de la Torre, Dechenes, DeFronzo, DeFronzo, DeKosky, Desai, Ding, Diniz, Droge, Dunn, d’Alessio, Eckles-Smith, Elahi, Elias, Elias, Elias, Fagot-Campagna, Fantuzzi, Farr, Fassbender, Ferrannini, Ferrannini, Ferrannini, Festa, Finch, Finkel, Franceschi, Freund, Fridlyand, Friedman, Frohman, Frolich, Fruhbeck, Fujimoto, Furukawa, Gabbita, Gabriely, Gazzaley, Gemma, Gibson, Gibson, Giunta, Gold, Gonzalez, Good, Granholm, Gray, Greenwood, Griffin, Gunning-Dixon, Gupta, Guttmann, Haan, Handschin, Harvey, Haslam, Heistad, Heitner, Ho, Hosokawa, Howard, Hoyer, Hsu, Hu, Hultsch, Hynd, Iqbal, Itateyama, Iyo, Izumi, James, Jankowsky, Janson, Jia, Joseph, Juhan-Vague, Kaasinen, Kanoski, Kennedy, Kirwan, Kissebah, Kitani, Klann, Klann, Knapp, Koenig, Kuk, Kumar, Kumari, Kuo, Kuriyama, Kuriyama, Laakso, Lamarche, Langan, Lau, Launer, Lee, Leibson, Leone, Lesser, Li, Lippa, Luchsinger, MacKnight, Magnusson, Maier, Manev, Mantena, Massaad, Matia, Matsuzawa-Nagata, Mattson, Mattson, Mattson, Mattson, McClearn, McNay, McNay, Medawar, Mendall, Meng, Messier, Michikawa, Miller, Miller, Milne, Moller, Moreira, Morin, Morrison, Muckle, Nag, Nagai, Navarro, Newton, Nielsen, Nisoli, Nunomura, Nyberg, Oakes, Ogawa, Oomura, Osmond, Ott, O’Shaughnessy, Pacini, Paolisso, Park, Partridge, Pasinetti, Pasinetti, Patterson, Pedigo, Peila, Peiris, Perlmuter, Perry, Perry, Petrovitch, Pfluger, Picard, Pinteaux, Pistell, Qiu, Qu, Rasouli, Razay, Rinne, Rizza, Rizza, Robertson-Tchabo, Roher, Roman, Rosamond, Rowe, Sattler, Sayre, Scacchi, Scheff, Schmitt-Schillig, Shen, Shi, Shimokata, Smith, Smith, Smith, Sohal, Sonntag, Souza, Spulber, Stadtman, Stadtman, Steemburgo, Steen, Strauss, Svedberg, Tanner, Tariot, Taylor, Terao, Terao, Terry, Tha, Thiels, Thiels, Tohgi, Tschop, Urakawa, Uz, van der Heide, van Exel, Vannucchi, Volkow, Wahrenberg, Wang, Wang, Wang, Ward, Wenk, White, Wieringa, Williams, Winocur, Wong, Woods, Wu, Wu, Xiao, Yaffe, Yasui, Ye, Yudkin, Zhang, Zhao, Zlokovic   +302 more
core   +1 more source

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]

, 2015
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina, Beltran-Alvarez, Pedro, Berne, Paola, Bosch Calero, Cristina, Brugada, Josep, Brugada, Ramon, Campuzano, Oscar, Iglesias, Anna, Pérez, Carmelo, Pérez, Guillermo J., Ruiz Hernandez, Pablo M., Scornik, Fabiana S., Wangüemert, Fernando   +12 more
core   +2 more sources

Constructing dementia and dementia care: daily practices in a day care setting [PDF]

, 2005
• Summary:This article explores the ways in which dementia can be constructed and maintained by the actions, and received ideas concerning dementia, of social care staff practising in a local authority day care setting in the UK.The article is set ...
Parker, Jonathan
core   +1 more source

Where was it? : working memory as a predictor of passive vocabulary development in the third year of life [PDF]

, 2016
The objective of the presented research was to test whether working memory, measured using the Spin the Pots task, is an important factor in passive vocabulary development in 2- and 3-year-old children. Two longitudinal studies were conducted.
Białecka-Pikul, Marta, Byczewska-Konieczny, Karolina, Kosno, Magdalena   +2 more
core   +1 more source

Isosorbide dinitrate, with or without hydralazine, does not reduce wave reflections, left ventricular hypertrophy, or myocardial fibrosis in patients with heart failure with preserved ejection fraction [PDF]

, 2017
Background-Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling.
Akers, Scott, Beraun, Melissa, Chirinos, Julio A., Chittams, Jesse, Haines, Philip G., Koppula, Maheswara R., Rawat, Deepa, Segers, Patrick, Shiva-Kumar, Prithvi, Soto-Calderon, Haideliza, Townsend, Raymond R., Varakantam, Swapna, Witschey, Walter R., Zamani, Payman   +13 more
core   +1 more source