RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre +68 more
core +3 more sources
Cancer anorexia: hypothalamic activity and its association with inflammation and appetite-regulating peptides in lung cancer [PDF]
Background Energy homeostasis is mediated by the hypothalamus, whose inflammation-induced functional derangements contribute to the onset of anorexia in cancer.
Arezzo di Trifiletti +39 more
core +1 more source
Heart transplantation in a patient with primary malignant tumor
The article looks at a clinical case of a 31-year-old female with signs of paroxysmal ventricular tachycardia and Morgagni–Adams–Stokes syndrome. In April 2014, electrophysiological examination revealed a source of ventricular tachycardia localized in ...
E. E. Kliver +4 more
doaj +1 more source
Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami +302 more
core +1 more source
Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina +12 more
core +3 more sources
Cardiac pacing in the 1980s: Treatment and techniques in transition [PDF]
The pacemaker of the 1980s is designed to maintain atrioventricular synchrony through dual-chamber pacing. This pacemaker is multiprogrammable and capable of telemetric transmission of biologic, electronic and electrophysiologic data.
Parsonnet, Victor, Bernstein, Alan D.
core +1 more source
Quasi-static imaged-based immersed boundary-finite element model of human left ventricle in diastole [PDF]
SUMMARY: Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary ...
Balay +59 more
core +1 more source
The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]
Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core +1 more source
Central Sensitivity Symptoms and Autistic Traits in Autistic and Non-Autistic Adults. [PDF]
ABSTRACT Central sensitivity syndromes (CSSs) are a group of health conditions thought to include an underlying sensitisation of the central nervous system. Evidence suggests autistic adults experience poorer physical health than the general population and are more likely to have a CSS. This study examined CSS diagnoses and symptoms in autistic and non‐
Grant S, Norton S, Hoekstra RA.
europepmc +2 more sources
Where was it? : working memory as a predictor of passive vocabulary development in the third year of life [PDF]
The objective of the presented research was to test whether working memory, measured using the Spin the Pots task, is an important factor in passive vocabulary development in 2- and 3-year-old children. Two longitudinal studies were conducted.
Białecka-Pikul, Marta +2 more
core +1 more source

