The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]
PLoS ONE, 2015 The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He +7 more
doaj +1 more source
Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease
Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 74-88, July 2026.Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani +14 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
ADAMTS-15 has a tumor suppressor role in prostate cancer
, 2020 Extracellular matrix remodeling has emerged as an important factor in many cancers. Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 ...
ED Williams (9893567) +4 more
core
Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]
, 2009 The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Hársfalvi, Jolán +9 more
core +1 more source
Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants. [PDF]
PLoS ONE, 2015 Border Disease (BD), caused by Pestivirus from the family Flaviviridae, leads to serious reproductive losses and brain anomalies such as hydranencephaly and cerebellar hypoplasia in aborted fetuses and neonatal lambs.
Gungor Cagdas Dincel, Oguz Kul
doaj +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Thrombotic thrombocytopenic purpura in IgG4‐related disease with severe deficiency of ADAMTS‐13 activity and IgG4 autoantibody against ADAMTS‐13 [PDF]
Arthritis Care & Research, 2011 IgG4-related disease is a recently recognized group characterized by elevated serum IgG4 levels and prominent lymphoplasmacytic infiltration of IgG4-positive cells into multiple organs (1). The condition was first described in relation to the pancreas (i.e., autoimmune pancreatitis [AIP] [2]), but since then many other inflammatory conditions ...
Takako, Saeki +10 more
openaire +2 more sources
ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion
Kaohsiung Journal of Medical Sciences, 2017 A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function.
Meryem Kuru Pekcan +6 more
doaj +1 more source