Results 81 to 90 of about 4,617,382 (195)

Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13 [PDF]

Seminars in Thrombosis and Hemostasis, 2012
Thrombotic microangiopathy (TMA) is a term used to describe a group of disorders characterized by hemolytic anemia (with prominent red blood cell fragmentation), thrombocytopenia, and thrombosis in the microvasculature. It may be used when describing patients with thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, atypical hemolytic ...
Kent, Chapman, Michael, Seldon, Ross, Richards   +2 more
openaire   +2 more sources

Platelet-derived VWF-cleaving metalloprotease ADAMTS-13 [PDF]

Journal of Thrombosis and Haemostasis, 2005
The adhesion ligand von Willebrand factor (VWF) is synthesized and stored in vascular endothelial cells and megakaryocytes/platelets. As in endothelial cells, platelet VWF also contains ultra-large (UL) multimers that are hyperactive in aggregating platelets.
L, Liu, H, Choi, A, Bernardo, A L, Bergeron, L, Nolasco, C, Ruan, J L, Moake, J-F, Dong   +7 more
openaire   +2 more sources

ADAMTS‐13: double trouble for von Willebrand factor [PDF]

Journal of Thrombosis and Haemostasis, 2010
See also Yeh HC, Zhou Z, Choi H, Tekeoglu S, May W III, Wang C, Turner N, Scheiflinger F, Moake JL, Dong JF. Disulfide bond reduction of von Willebrand factor by ADAMTS-13. This issue, pp 2778–88.
P J, Lenting, G, Rastegarlari
openaire   +2 more sources

ADAMTS-15 has a tumor suppressor role in prostate cancer

, 2020
Extracellular matrix remodeling has emerged as an important factor in many cancers. Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 ...
ED Williams (9893567), Marley Binder (13083339), DR McCulloch (14470866), Alister Ward (13059717), S McCoombe (13616395)   +4 more
core  

Pancreatitis and Myocardial Infarction as Complications of Thrombotic Thrombocytopenic Purpura: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Thrombotic thrombocytopenic purpura (TTP) is a rare disease with a mortality rate of 90% if not treated promptly. Due to limited clinical experience and sometimes atypical presentation, early detection of TTP is not always easy. The pathophysiological mechanisms underlying TTP can accelerate thrombus formation and vascular occlusion ...
Farid Poursadegh, Motahhareh Karimoddini, Mohsen Seddigh‐shamsi, Najme Mohajer   +3 more
wiley   +1 more source

ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion

Kaohsiung Journal of Medical Sciences, 2017
A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function.
Meryem Kuru Pekcan, Esma Sarıkaya, Aytekin Tokmak, Murat Alışık, Afra Alkan, Gülnur Özakşit, Özcan Erel   +6 more
doaj   +1 more source

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source

Serum ADAMTS-13 Levels as an Indicator of Portal Vein Thrombosis

Gastroenterology Research and Practice, 2018
Background. Coagulation disorders in patients with liver cirrhosis are a common clinical problem. Cirrhosis should be considered a state of impaired blood clotting or an imbalance of the whole coagulation system.
Tomasz Mikuła, Joanna Kozłowska, Wojciech Stańczak, Mariusz Sapuła, Aleksandra Różyk, Alicja Wiercińska-Drapało   +5 more
doaj   +1 more source

ADAMTS-13: diagnóstico de laboratorio

, 2020
ADAMTS-13 es una desintegrina y metaloproteasa, zinc y calcio dependiente, codificada en el cromosoma humano 9q34. Su rol primario es clivar los multímeros ultra grandes del factor de Von Willebrand (ULVWF) originando sus diferentes formas moleculares ...
Aranda Aranda, Federico Manuel, Larrañaga, Gabriela de, Lencinas, Gisela, Peres, Silvia   +3 more
core  

ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes [PDF]

, 2006
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes are a recently described group of metalloproteinases. The substrates degraded by ADAMTS-1, -4 and -5 suggests that they play a role in turnover of extracellular matrix in the
Woodroofe, N., Surr, J., Allan, S., Stock, C. J., Cross, A. K., Haddock, G., Buttle, D. J., Bunning, R. A.   +7 more
core   +1 more source