Results 121 to 130 of about 3,339,678 (311)

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Acculturation and Psychological Adaptation

, 2021
UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP)
openaire   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Adaptation and Development: Whose Goals and Priorities Count?

, 2010
It has been argued that adaptation to climate change should be integrated with development activities, and that it is time to pursue its 'mainstreaming' within such programmes (Burton 2009).
Nalau, Johanna, Heyd, T.
core  

Adaptor of last resort? An economic perspective on the government’s role in adaptation to climate change [PDF]

, 2013
 Individuals and societies have always adapted to change, whether catastrophic or slow onset. Over the last two centuries, however, governments have significantly extended their role as ultimate social manager of risk.
Leo Dobes, Patrick Doupe, Frank Jotzo
core  

The use of heuristics in quick decision-making as a manifestation of bounded rationality under stress

Revista Cubana de Medicina Militar
Introduction: The relevance of this study is due to the increasing influence of quick and incomplete decision-making within crisis environments, particularly in extreme social or organizational contexts.
Mykhailo Zhylin, Tetiana Morozova, Viktoriia Malysh, Svitlana Bondarevych, Olena Medianova   +4 more
doaj  

Relationship between Psychological Hardiness and Social Support with Adaptation: A Study on Individuals with Multiple Sclerosis

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2013
Introduction: Psychological hardiness is a personal factor and social support is regarded as an environmental factor that can facilitate adjustment to disease.
N hasan neghad, F hadavand khani, P Ahmadi, Z khanjani   +3 more
doaj  

How do relocatees adapt? a longitudinal investigation into the spatiotemporal evolution and internal mechanisms of social adaptation in post-relocation life

Geocarto International
This study employs longitudinal survey data (2020–2024) from 638 poverty-alleviation resettlement households in China. Using Wilcoxon test, Kruskal-Wallis test, and structural equation model, it systematically analyses the spatiotemporal evolution ...
Xueyue Hu, Zhongfa Zhou, Fang Tang, Yating Jing, Ding Ding, Tengxian Zhang, Yongliu Yang, Yaopeng Sun   +7 more
doaj   +1 more source