Results 131 to 140 of about 2,630,733 (260)

Spatial‐Scale Evolutionary Bias Sheds Light on the Latitudinal Diversity Gradient

Ecology and Evolution
The latitudinal diversity gradient (LDG) is observed across various biological groups, but its causes remain debated. Here, using Escherichia coli as a model system, we experimentally tested whether spatial‐scale evolutionary bias (SSEB)—the tendency for
Haoyuan Wu, Donghui Xu, Yonghua Wu
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Percentual gain change of all adaptation blocks in relation to baseline gain.

, 2015
In adaptation 1 (A) and 2 (B) subjects show a similar improvement of learning performance in all conditions. After the 2h break/one night of sleep subjects in the free viewing condition show a significantly higher gain reduction than those in the VD ...
Wolfgang Heide (721255), Christoph Helmchen (501920), Caroline Voges (721254), Andreas Sprenger (320807)   +3 more
core   +1 more source

Dynamic Adaptation in Fly Motion Vision [PDF]

, 2006
Sensory neurons process and convey information about our surroundings, providing the physiological basis for how we interact with the external world. In order to understand neuronal responses we must identify the rules governing how sensory information ...
Flanagin, Virginia, Flanagin, V.
core   +1 more source

Multilateral funding for health adaptation and the health co-benefits of climate mitigation: An observational study

Environment International
Background: The health impacts of climate change have been increasingly recognised for the past years. However, it remains unclear how this has translated into funding for health adaptation and health co-benefits of climate mitigation.
Ana-Catarina Pinho-Gomes, Louis Jamart
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Opportunities, Threats, and Strategic Choice: The Modifying Role of Emotion

Administrative Sciences
Business models often transform due to adaptation in response to external changes. However, relatively little is known about what causes these types of adaptations.
Camilla Aarøen, Marcus Selart
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Adaptation across the 2D population code explains the spatially distributive nature of motor learning.

PLoS Computational Biology
In current computational models on oculomotor learning 'the' movement vector is adapted in response to targeting errors. However, for saccadic eye movements, learning exhibits a spatially distributive nature, i.e.
Jana Masselink, Markus Lappe
doaj   +1 more source