Results 71 to 80 of about 3,755,469 (301)
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Adaptive PBIL algorithm and its application to solve scheduling problems
, 2006 An adaptive population-based incremental learning algorithm (APBIL) is presented basing on analyzing the characteristics of traditional PBIL algorithm in this paper. Overcoming disadvantages of traditional PBIL algorithm, the proposed APBIL algorithm can
Hali Pang +5 more
core +1 more source
Adaptive Enhancement of X-Band Marine Radar Imagery to Detect Oil Spill Segments
Sensors, 2017 Oil spills generate a large cost in environmental and economic terms. Their identification plays an important role in oil-spill response. We propose an oil spill detection method with improved adaptive enhancement on X-band marine radar systems.
Peng Liu, Ying Li, Jin Xu, Xueyuan Zhu
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
An Improved Firefly Algorithm with Adaptive Strategies [PDF]
, 2012 Firefly Algorithm (FA) is a powerful swarm intelligence algorithm inspired by the flash phenomenon of the fireflies. However, it has weaknesses on optimizing high-dimensional problems.
Zhu YL(朱云龙) +3 more
core
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Analysis of the sign regressor least mean fourth adaptive algorithm [PDF]
, 2011 A novel algorithm, called the signed regressor least mean fourth (SRLMF) adaptive algorithm, that reduces the computational cost and complexity while maintaining good performance is presented.
Zerguine, A., Ulla Faiz, M., Zidouri, A.
core +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source