Results 21 to 30 of about 3,957,324 (204)

How Dutch Institutions Enhance the Adaptive Capacity of Society [PDF]

, 2010
This report examines the adaptive capacity of the institutional framework of the Netherlands to cope with the impacts of climate change. Historically, institutions have evolved incrementally to deal with existing social problems.
Termeer, C., Termeer, C.J.A.M., Bergsma, E.J., Klostermann, J.E.M., Jong, P.., van den Brink, M., Nootebooms, S., Jong, P., Brink, M.H., van den, van den Brink, M.H., Bergsma, E., Klostermann, J., Biesbroek, G.R., Meijerink, S., Biesbroek, R., Termeer, K., Gupta, J., van den Brink, M.A., Nooteboom, S.G.   +18 more
core  

THE WEAKEST LINK HYPOTHESIS FOR ADAPTIVE CAPACITY: AN EMPIRICAL TEST [PDF]

Yohe and Tol (2001) built an indexing method for vulnerability based on the hypothesis that the adaptive capacity for any system facing a vector of external stresses could be explained by the weakest of eight underlying determinants – the so-called ...
Richard S.J. Tol, Gary W. Yohe
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

What about me? Factors affecting individual adaptive coping capacity across different populations [PDF]

, 2013
 When and why will people adapt to climate change? We conducted a number of studies examining the psychological drivers of individual adaptation to climate change across different populations. We used a variety of methodologies including interviews,
Stephen Lewandowsky, Sally Russell, Kerrie Unsworth   +2 more
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Household level adaptive capacity of fishing communities in Western Mindanao, Philippines to the changing climate | JBES 2020

, 2020
Climate change has been affecting many coastal communities around the world. With the location of the Philippines in the tropics, the country is vulnerable to the impacts brought by this phenomenon affecting the safety, livelihood, and income ...
Yhebron J. Lagud, Cesar G. Demayo
core   +1 more source

Towards a characterisation of adaptive capacity: A framework for analysing adaptive capacity at the local level

, 2010
Interest is growing in supporting vulnerable people and communities to adapt to the impacts of a changing climate, and there is a general assumption that there are close links between development and adaptation.
Levine, Simon, Jones, Lindsey, Ludi, Eva
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source