Results 181 to 190 of about 2,359,184 (334)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A cholinergic spinal pathway for the adaptive control of breathing. [PDF]

Cell Rep
Lin M, Calabrese GB, Incognito AV, Moore MT, Agarwal A, Wilson RJA, Zagoraiou L, Sharples SA, Miles GB, Philippidou P.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Digital twin-driven deep learning prediction and adaptive control for coal mine ventilation systems. [PDF]

Sci Rep
Yang X, Li H.
europepmc   +1 more source

Design and build implementation of fuzzy logic control on adaptive ventilator [PDF]

Suwarsono Suwarsono, Budiono Budiono, Deny Fajar Hidayat, Gigih Dwi Raharjo, Haneef Nouval Alannibras Humaidi   +4 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Adaptive control of DC-DC power converter: design and experimental investigation with constant power load. [PDF]

Sci Rep
Nizami TK, Gangula SD, Udumula RR, Chakravarty A, Mangaraj M, Ahmad F, Veerendra AS.   +6 more
europepmc   +1 more source

Adaptive Neural-Network-Based Fault Tolerant Control for Autonomous Vehicles With Dynamic Output Constraints

Zhaoyu Qiu, Xiaoyuan Zhu, Anh‐Tu Nguyen, Guodong Yin   +3 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Robust adaptive control with lumped model uncertainty and wind disturbance estimation for airship trajectory tracking. [PDF]

PLoS One
Wasim M, Ali A, Saleem F, Shaikh IUH, Iqbal J.   +4 more
europepmc   +1 more source