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Trends in Adaptive Design Methods in Dialysis Clinical Trials: A Systematic ReviewPlain-Language Summary [PDF]
Kidney Medicine, 2021 Rationale & Objective: Adaptive design methods are intended to improve the efficiency of clinical trials and are relevant to evaluating interventions in dialysis populations.
Conor Judge +6 more
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Robot End-Effectors Adaptive Design Method Based on Embedding Domain Knowledge into Reinforcement Learning [PDF]
SensorsExisting robot end-effectors design methods lack structured domain prior knowledge support and have insufficient interaction with the environment, making it difficult to guarantee the accuracy of the design results.
Yong Zhu +3 more
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Adaptive Incentive Design [PDF]
IEEE Transactions on Automatic Control, 2021 We apply control theoretic and optimization techniques to adaptively design incentives. In particular, we consider the problem of a planner with an objective that depends on data from strategic decision makers. The planner does not know the process by which the strategic agents make decisions. Under the assumption that the agents are utility maximizers,
Lillian J. Ratliff, Tanner Fiez
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Advanced Industrial and Engineering Polymer Research, 2021 Continuous lattice fabrication is a newly introduced method for additive manufacturing of fiber-reinforced thermoplastic composites that allows to deposit material where it is needed.
Nicole Aegerter +4 more
doaj +1 more source
Principle and Control of Active Engine Mount Based on Magnetostrictive Actuator
Chinese Journal of Mechanical Engineering, 2022 Engine mount system affects the automobile NVH performance. Active mounts would achieve excellent vibration isolation and relative displacement control performance in a broad frequency bandwidth by outputting controlled force to the mounting system.
Zhiyuan Si +3 more
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Разработка и регистрация лекарственных средств, 2023 Introduction. Citicoline is an endogenous nucleoside consisting of cytidine and choline linked by a diphosphate bridge that is involved in the synthesis of membrane phospholipids.
A. N. Arevefa +8 more
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Industrial Heritage Rethinking: Flexibility Design for Eco-Friendly Environments
Buildings, 2023 The conscious and efficient reuse of historic buildings has turned out to be a fundamental point of European programs for the management and conservation of the Architectural Heritage.
Stefania De Gregorio +2 more
doaj +1 more source
Mathematical Modelling for Optimal Vaccine Dose Finding: Maximising Efficacy and Minimising Toxicity
Vaccines, 2022 Vaccination is a key tool to reduce global disease burden. Vaccine dose can affect vaccine efficacy and toxicity. Given the expense of developing vaccines, optimising vaccine dose is essential. Mathematical modelling has been suggested as an approach for
John Benest +3 more
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Vaccines, 2022 Mathematical modelling methods and adaptive trial design are likely to be effective for optimising vaccine dose but are not yet commonly used. This may be due to uncertainty with regard to the correct choice of parametric model for dose-efficacy or dose ...
John Benest +3 more
doaj +1 more source
Annual Review of Pharmacology and Toxicology, 2012 We review adaptive designs for clinical trials, giving special attention to the control of the Type I error in late-phase confirmatory trials, when the trial planner wishes to adjust the final sample size of the study in response to an unblinded analysis of interim estimates of treatment effects. We point out that there is considerable inefficiency in
Tze Leung, Lai +2 more
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