Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Foregasting with adaptive filtering [PDF]
Revue française d'automatique, informatique, recherche opérationnelle. Recherche opérationnelle, 1973 Wheelwright, Steven C. +1 more
openaire +2 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Learning algorithms for adaptive digital filtering [PDF]
, 1993 In this thesis, we consider the problem of parameter optimisation in adaptive digital filtering. Adaptive digital filtering can be accomplished using both Finite Impulse Response (FIR) filters and Infinite Impulse Response Filters (IIR) filters. Adaptive
Nambiar, Raghu
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An Adaptive Filter for Nonlinear Multi-Sensor Systems with Heavy-Tailed Noise. [PDF]
Sensors (Basel), 2020 Dong X, Chisci L, Cai Y.
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Efficient Implementations of Complex and Real Valued Filter Banks for Comparative Subband Processing with an Application to Adaptive Filtering (301kB) [PDF]
, 1998 In this paper, we discuss efficient methods to implement correlation type algorithms in subbands. Based on a polyphase representation, a modulated GDFT filter bank with arbitrary integer decimation ratio can be performed at minimum cost, yielding complex
Weiss, Stephan +5 more
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Efficient implementation of LMS adaptive filter-based FECG extraction on an FPGA. [PDF]
Healthc Technol Lett, 2020 Vasudeva B +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
An adaptive square-root unscented Kalman filter for underwater Vehicle navigation [PDF]
, 2014 In order to increase the approximation accuracy of the state estimate of nonlinear systems and to guarantee numerical stability of the unscented Kalman filter (UKF), a novel adaptive square-root unscented Kalman filter (ASRUKF) based on modified Sage ...
Liu KZ(刘开周) +2 more
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