Results 61 to 70 of about 309,335 (260)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Managing Adaptivity in Parallel Systems [PDF]

, 2013
The management of non-functional features (performance, security, power management, etc.) is traditionally a difficult, error prone task for programmers of parallel applications. To take care of these non-functional features, autonomic managers running policies represented as rules using sensors and actuators to monitor and transform a running parallel
Aldinucci M, DANELUTTO, MARCO, Kilpatrick P, MONTANGERO, CARLO, SEMINI, LAURA   +4 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Adaptive Water Resources Management Based on a Matrix of Approaches and an Integral Status Indicator [PDF]

Problemi Ekonomiki
The article substantiates and validates a methodological framework for adaptive water resource management in Ukraine, integrating a matrix of conceptual approaches (sectoral, ecosystem, integrated, adaptive) with an indicator-based assessment of water ...
Khvesyk Mykhailo A. , Levkovska Ludmyla V. , Mandzyk Valerii M. , Cherednichenko Iuliia G.   +3 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

A Framework for Resilience-based Governance of Social-Ecological Systems

Ecology and Society, 2013
Panarchy provides a heuristic to characterize the cross-scale dynamics of social-ecological systems and a framework for how governance institutions should behave to be compatible with the ecosystems they manage.
Ahjond S. Garmestani, Melinda Harm. Benson   +1 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Optimized fertilizer–microbe ratios enhance synergistic restoration of alpine mining ecosystems

Frontiers in Microbiology
IntroductionTo address the critical issues of soil fertility depletion, poor vegetation establishment, and functional degradation of microbial communities in degraded alpine mining ecosystems, this study focuses on the Muli coal mine on the Qinghai–Tibet
Zongcheng Cai, Zongcheng Cai, Zongcheng Cai, Jianjun Shi, Jianjun Shi, Jianjun Shi, Shouquan Fu, Shouquan Fu, Shouquan Fu, Fayi Li, Fayi Li, Fayi Li, Liangyu Lv, Liangyu Lv, Liangyu Lv, Qingqing Liu, Qingqing Liu, Qingqing Liu, Hairong Zhang, Hairong Zhang, Hairong Zhang, Shancun Bao, Shancun Bao, Shancun Bao   +23 more
doaj   +1 more source

Personal Determinants of Formation Disease Adaptation in Patients with Active Pulmonary Tuberculosis: a Comparative Analysis from the Standpoint of Gender Approach [PDF]

Психологическая наука и образование (2007. Online), 2014
We present the design and results of empirical research, facing the actual problem of integration of theoretical and methodological knowledge of different areas of psychology to solve actual applied problems of modern physical medicine.
Sevostyanova M.S.,
doaj  

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source