Results 61 to 70 of about 310,845 (260)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Assessment of high-light adaptation and screening of superior oat germplasm

Frontiers in Plant Science
BackgroundIn the context of climate warming, high-light stress has become a major environmental constraint on crop photosynthetic efficiency and growth.
Bohong Zhang, Bohong Zhang, Xiang Ma, Xiang Ma, Zeliang Ju, Zeliang Ju, Jingjie Liu, Jingjie Liu, Zhifeng Jia, Zhifeng Jia   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The Adaptive Water Resources Management Based on a Matrix of Approaches and an Integral Status Indicator [PDF]

Problemi Ekonomiki
The article substantiates and validates a methodological framework for adaptive water resource management in Ukraine, integrating a matrix of conceptual approaches (sectoral, ecosystem, integrated, adaptive) with an indicator-based assessment of water ...
Khvesyk Mykhailo A. , Levkovska Ludmyla V. , Mandzyk Valerii M. , Cherednichenko Iuliia G.   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A Framework for Resilience-based Governance of Social-Ecological Systems

Ecology and Society, 2013
Panarchy provides a heuristic to characterize the cross-scale dynamics of social-ecological systems and a framework for how governance institutions should behave to be compatible with the ecosystems they manage.
Ahjond S. Garmestani, Melinda Harm. Benson   +1 more
doaj   +1 more source

Managing Adaptivity in Parallel Systems [PDF]

, 2013
The management of non-functional features (performance, security, power management, etc.) is traditionally a difficult, error prone task for programmers of parallel applications. To take care of these non-functional features, autonomic managers running policies represented as rules using sensors and actuators to monitor and transform a running parallel
Aldinucci M, DANELUTTO, MARCO, Kilpatrick P, MONTANGERO, CARLO, SEMINI, LAURA   +4 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Optimized fertilizer–microbe ratios enhance synergistic restoration of alpine mining ecosystems

Frontiers in Microbiology
IntroductionTo address the critical issues of soil fertility depletion, poor vegetation establishment, and functional degradation of microbial communities in degraded alpine mining ecosystems, this study focuses on the Muli coal mine on the Qinghai–Tibet
Zongcheng Cai, Zongcheng Cai, Zongcheng Cai, Jianjun Shi, Jianjun Shi, Jianjun Shi, Shouquan Fu, Shouquan Fu, Shouquan Fu, Fayi Li, Fayi Li, Fayi Li, Liangyu Lv, Liangyu Lv, Liangyu Lv, Qingqing Liu, Qingqing Liu, Qingqing Liu, Hairong Zhang, Hairong Zhang, Hairong Zhang, Shancun Bao, Shancun Bao, Shancun Bao   +23 more
doaj   +1 more source