Results 91 to 100 of about 14,736 (262)

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

From Ambition to Action: Barriers and Enablers for the Inclusion of Indigenous Peoples and Local Communities in the Kunming–Montreal Biodiversity Framework and the Role of Non‐State Bridge Organizations

Advanced Science, EarlyView.
Graphical abstract illustrating the transition from global biodiversity ambition to on‐the‐ground implementation of the Kunming–Montreal Global Biodiversity Framework after COP16, highlighting the roles of governments, non‐state actors, scientific knowledge systems, and resource mobilization in achieving transformative biodiversity outcomes.
Susan Enechojo Ogbe, Jinfeng Zhou, Linda Wong, Jiachen Gao   +3 more
wiley   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Asymmetric Multifractal Efficiency in Global Trade-Related Markets: Evidence from Oil, Freight and Exchange Rate Dynamics

Fractal and Fractional
The paper examines the multifractal and asymmetric behavior of oil, freight and exchange rate markets in the global trade system with the help of the Asymmetric Multifractal Detrended Fluctuation Analysis (AMF-DFA) technique.
Fang He, Ming Jiang
doaj   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Comovement of african stock markets: Any influence from the COVID-19 pandemic?

Heliyon
Utilising daily data from twelve Sub-Saharan stock markets we investigate the co-movements and information transmission among African stock markets as a result of the impact of COVID while employing multiple wavelet techniques and applying the Complete ...
Peterson Owusu Junior, Joseph Emmanuel Tetteh, Bernice Nkrumah-Boadu, Abigail N.K. Adjei   +3 more
doaj   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Photonic‐Enabled Energy‐Efficient Transparent Neuromorphic Computing Devices: A Review

Advanced Science, EarlyView.
Transparent photonic neuromorphic computing devices merge optics and brain‐inspired computing to overcome von Neumann bottlenecks with ultrafast, low‐energy processing. By exploiting transparent oxides, 2D materials, phase‐change materials, and hybrid heterostructures, these platforms enable photonic synapses, memory, and logic for see‐through edge ...
Shuvaraj Ghosh, Ki‐bum Lee, Junghyeon Lee, Seunghee Cho, Malkeshkumar Patel, Hangfei Li, Yu Wen, Ye Zhou, Joondong Kim   +8 more
wiley   +1 more source

Solar‐Driven Bifunctional Adsorption‐Storage Films for Ultra‐Fast Dehumidification and Freshwater Supply in Low‐carbon Buildings

Advanced Science, EarlyView.
Bifunctional adsorption‐storage films enable autonomous indoor humidity regulation and freshwater harvesting, rapidly decreasing relative humidity from 90.7% to 21.6% within one hour while producing 1.1 kg·m−2·day−1 of water, offering a passive route towards energy‐efficient humidity control and sustainable indoor environments. ABSTRACT Indoor humidity
Yuechao Chao, Junwei Liu, Zhihua Zhou, Yahui Du, Hailu Wei, Haibin Yang, Xueqing Yang, Cheng Wang, Zhenzhong Zeng, Hongzhi Cui, Jinyue Yan   +10 more
wiley   +1 more source