Results 91 to 100 of about 224,801 (264)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Asymmetric clipped optical OFDM adaptive indexing modulation scheme under turbulent channels

Tongxin xuebao
Given the issue that existing optical orthogonal frequency division multiplexing (OFDM) with index modulation (OOFDM-IM) struggle to adapt to channel variations, which results in limitations on transmission rate.
WANG Huiqin, PEI Yanhao, WANG Zhen, TANG Qihan, RU Hui, ZHANG Hongyan   +5 more
doaj  

AQAM under high time delay spread conditions

Journal of Measurement Science and Instrumentation, 2012
An analysis process is described for adaptive quadrature amplitude modulation（AQAM）of constant-power constant-symbol-rate over frequency-selective Rayleigh fading channels with inter symbol interference（ISI）and Gaussian noise.The delay spread resistance ...
SHAN Xiao-hong, ZHU Xiu-shan, GUO Yin-jing, LIU Zhi-wen   +3 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Use of Delayed Channel Estimation Results in Adaptive Modulation

Journal of Measurement Science and Instrumentation, 2011
In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD（Tolerable Average Use Delay）is ...
Xiao-hong SHAN, Feng-ying WANG, Yin-jing GUO, Jin LI   +3 more
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Adaptive modulation of brain hemodynamics across stereotyped running episodes. [PDF]

Nat Commun, 2020
Bergel A, Tiran E, Deffieux T, Demené C, Tanter M, Cohen I.   +5 more
europepmc   +1 more source

New Adaptive Data Transmission Scheme Over HF Radio

Al-Khawarizmi Engineering Journal, 2008
Acceptable Bit Error rate can be maintained by adapting some of the design parameters such as modulation, symbol rate, constellation size, and transmit power according to the channel state.An estimate of HF propagation effects can be used to design an ...
Adil H. Ahmad, Abdul-Karim A.R. Kadhim, Khalifa Abboud Salim   +2 more
doaj