Results 81 to 90 of about 33,181 (245)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Adaptive Neural Output Feedback Control for Uncertain Robot Manipulators with Input Saturation
Complexity, 2017 This paper presents an adaptive neural output feedback control scheme for uncertain robot manipulators with input saturation using the radial basis function neural network (RBFNN) and disturbance observer.
Rong Mei, ChengJiang Yu
doaj +1 more source
Adaptive Observations: A Feasibility Study
Monthly Weather Review, 1999 The feasibility of the recently proposed concept of adaptive observations is tested on a typical case of poorly forecast North Atlantic cyclogenesis. Only numerical tools are employed, no special observations. Although based on simulated data, this study addresses both theoretical and practical problems of adaptive observations.
Thierry Bergot +3 more
openaire +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Nonlinear Fault-Tolerant Control for Hypersonic Flight Vehicle With Multi-Sensor Faults
IEEE Access, 2018 This paper presents a nonlinear fault-tolerant control (FTC) and sensor fault diagnosis for longitudinal dynamics of hypersonic flight vehicle. A nominal sliding mode control is developed to track the reference command of velocity and altitude on the ...
Fuyang Chen, Juan Niu, Gengqian Jiang
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Robustness of Double-Adaptive Observers
Transactions of the Institute of Systems, Control and Information Engineers, 1992 The usual process identification methods for parameter adjustment, along with dead zone, are effective in providing a robust adaptive observer of an unknown plant under uncertain input disturbance and output measurement noise. But it is difficult to decide the size of the dead zone due to the lack of knowledge concerning the disturbance.
Yong Li, Yoh YONEZAWA, Yukio NISHIMURA
openaire +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source