Results 91 to 100 of about 3,629,152 (245)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling. [PDF]

open access: yesCell Mol Gastroenterol Hepatol, 2021
Yan S   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A dynamic modelling environment for the evaluation of wide area protection systems [PDF]

open access: yes, 2008
This paper introduces the concept of dynamic modelling for wide area and adaptive power system protection. Although not limited to these types of protection schemes, these were chosen due to their potential role in solving a multitude of protection ...
Abdulhadi, I.F.   +7 more
core   +1 more source

Adaptive protection methods for aircraft applications

open access: yes, 2010
Complex certification issues aside, aircraft electrical systems possess a number of attributes that present good opportunities for the implementation of adaptive protection systems.
Burt, Graeme   +7 more
core   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Adaptive oxidation protection in C/Y

open access: yesJournal of Materiomics
Limiting oxygen ingress through surface-connected defects is critical for improving the oxidation durability of carbon-fiber-reinforced ceramic-matrix composites at high temperatures.
Kuanhong Zeng   +7 more
doaj   +1 more source

A Review: Development of a Microdose Model for Analysis of Adaptive Response and Bystander Dose Response Behavior

open access: yesDose-Response, 2008
Prior work has provided incremental phases to a microdosimetry modeling program to describe the dose response behavior of the radio-protective adaptive response effect.
Bobby E. Leonard
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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