Results 71 to 80 of about 3,480,946 (289)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Research on a dynamic security defense system for cloud-native education platforms using mixture-of-experts model

Dianzi Jishu Yingyong
To address the complex dynamic security threats confronting cloud-native education platforms and the limitations of traditional defense mechanisms—notably weak environmental awareness, lack of intelligent decision-making, inadequate generalization ...
Xu Wenjing, An Ning, Liu Zhuhui, Yu Zhong   +3 more
doaj   +1 more source

Efficacy of Insecticides against Fall Armyworm, Spodoptera frugiperda (Lepidoptera, Noctuidae) in Maize

Journal of Bioresource Management, 2022
Fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera: Noctuidae) is most destructive specie of genus Spodoptera for several agricultural crops. In Pakistan's Sindh province, the invasive fall armyworm Spodoptera frugiperda was first documented causing
Fawzan Masood Mian , Imtiaz Khan, Najeeb Ullah, Aqarab Husnain Gondal , Muhamad Saqib Ajmal , Muhammad Sajid Qureshi, Adnan Ihsan, Muhammad Raziq, Imran Qazi, Abdul Jabbar   +9 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Proteção adaptativa de alimentadores de distribuição de energia elétrica considerando geração distribuída [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2011A instalação de unidades de Geração Distribuída (GD) nas redes de distribuição de energia elétrica ...
Bittencourt, Annelise Anderson
core  

A Compr A Comprehensiv ehensive Review on Impact of Micr view on Impact of Microorganisms on Soil ganisms on Soil and Plant

Journal of Bioresource Management, 2022
Soils have the most diversified microbial communities of any environment on the planet. Bacteria, fungi, algae, and protozoa are all found in abundance in soil.
Tasaddaq Younas, Muhammad Umer, Aqarab Husnain Gondal , Huma Aziz, Muhammad Shehzad Khan   +4 more
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Stress Testing Adaptive Social Protection Systems in the Sahel

The Sahel region of Africa faces multiple crises, which further compound structural economic and human development challenges. The Sahel is one of the world’s poorest regions and displays some of the lowest
Coudouel, Aline, Saidi, Mira, Fuselli, Silvia   +2 more
core   +1 more source