Results 81 to 90 of about 3,459,920 (290)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Adaptive load shedding and regional protection

, 2009
The requirement for improved efficiency whilst maintaining system security necessitates the development of improved system analysis approaches and the development of advanced emergency control technologies.
Bevrani, Hassan, Ledwich, Gerard, Ford, Jason J.   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research on a dynamic security defense system for cloud-native education platforms using mixture-of-experts model

Dianzi Jishu Yingyong
To address the complex dynamic security threats confronting cloud-native education platforms and the limitations of traditional defense mechanisms—notably weak environmental awareness, lack of intelligent decision-making, inadequate generalization ...
Xu Wenjing, An Ning, Liu Zhuhui, Yu Zhong   +3 more
doaj   +1 more source

Radiation Worker Protection by Exposure Scheduling

Dose-Response, 2011
The discovery of the protective adaptive response of cells to a low dose of radiation suggests applications to radiation worker/first responder protection. Its use in cancer radiotherapy has been discussed in a separate publication.
Richard Blankenbecler
doaj   +1 more source

Adaptive electrothermal protection means for semiconductor converters.

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2017
Thermal management for power converters during normal operation and transient modes when electrical components are warmed up is an actual problem. This can be particularly important for converters with intermittent duty operation, e.g. power supplies for
R. A. Baraniuk, V. A. Todorenko, O. F. Bondarenko   +2 more
doaj   +1 more source

Additively Manufactured Dual-Faced Structured Fabric for Shape-Adaptive Protection. [PDF]

Adv Sci (Weinh), 2023
Tian Y, Chen K, Zheng H, Kripalani DR, Zeng Z, Jarlöv A, Chen J, Bai L, Ong A, Du H, Kang G, Fang Q, Zhao L, Qi HJ, Wang Y, Zhou K.   +15 more
europepmc   +1 more source

Watershed Protection Master Plan 2015 Update [PDF]

, 2015
This report updates the Watershed Protection Masterplan, expanding analysis from 17 to 49 watersheds. Similar to the 2001 report, there is an assessment of creek flooding, local flooding, erosion, and water quality.
City of Austin Watershed Protection Department
core   +1 more source