Results 141 to 150 of about 3,462,355 (290)

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Transcriptomic detection of Candidatus Allocryptoplasma (Anaplasmataceae) in Galápagos marine iguanas (Amblyrhynchus cristatus, Iguanidae)

Parasites & Vectors
Background Globally, the disease ecology of reptiles remains understudied, even for threatened and iconic species such as the Galápagos marine iguana (Amblyrhynchus cristatus).
Flora Uesseler, Lena Werner, Stefan Schaffer, Alejandro Ibáñez, Scott Glaberman, Diego Páez-Rosas, Juan M. Guayasamin, Michael Hofreiter, Sebastian Steinfartz, Franziska Anni Franke-Gerth   +9 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Remifentanil functions in the adaptive protection of cardiac function following ischemia. [PDF]

Exp Ther Med, 2017
Hou J, Wang H, Li X, Zhu Y.
europepmc   +1 more source

Adaptive current protection for three‐phase short‐circuit faults in active distribution networks

IET Renewable Power Generation
To address the impact of distributed generation (DG) access on the traditional protection configuration methods of distribution networks (DNs) and to facilitate the swift and effective protection of lines by protection devices under fault conditions, an ...
Shi Su, Yuan Li, Xuehao He, Qingyang Xie, Xiaolong Chen, Zhiyan Zheng, Botong Li, Jing Zhang   +7 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Executive summary & table of recommended strategies; State of Connecticut solid waste management plan : executive summary; Executive summary and table of recommended strategies excerpted from State of Connecticut solid waste management plan, amended December 2006

, 2006
Title from cover.; At head of title: State of Connecticut.; "Changing the Balance."; "Pursuant to Connecticut General Statutes Section 22a-228 and 22a-228-1(b) of the Regulations of Connecticut State Agencies (RCSA) ..."--T.p.
Connecticut. Dept. of Environmental Protection.
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MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Modelling and control of adaptive mechanical structures Proceedings

, 1998
Adaptive structures (smart structures) are autonomous structural systems with integrated multifunctional smart materials as actuators and sensors, connected by a control system, to facilitate adaptation to changing environmental conditions (e.g.
Gabbert, U. (comp.), Magdeburg Univ. (Germany). Innovationskolleg ''Adaptive Mechanische Systeme'' (ADAMES)   +1 more
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