We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach +4 more
wiley +1 more source
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity. [PDF]
Lin SY +4 more
europepmc +1 more source
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj +10 more
wiley +1 more source
Editorial: Exploring immune memory dynamics in chronic antigen exposure and disease progression: implications for immunotherapy. [PDF]
Caserta S, Pera A.
europepmc +1 more source
Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami +4 more
wiley +1 more source
Respiratory syncytial virus infection induces heterologous protection against SARS-CoV-2 through γδ T cell-mediated trained immunity and the activation of SARS-CoV-2-reactive mucosal T cells. [PDF]
Adam A +7 more
europepmc +1 more source
From Classical Bacterins to Recombinant Vaccines: Critical Aspects of the Immune Response in Ruminants. [PDF]
Loria J, Baldwin C, Lilenbaum W.
europepmc +1 more source
Nasal humoral immunity: the first line of protection against respiratory pathogens. [PDF]
Hansen L, Guthmiller JJ.
europepmc +1 more source
The adaptive immune receptors in a big data world. [PDF]
DeKosky BJ.
europepmc +1 more source

