Results 91 to 100 of about 3,459,920 (290)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

µPMU-based smart adaptive protection scheme for microgrids

Journal of Modern Power Systems and Clean Energy, 2019
The concepts of microgrids (MGs) and smart grid represent the recent targeted revolution towards fully smart electrical network integrated with high penetration of renewable energy sources (RESs).
Mohamed Salah Elbana, Nabil Abbasy, Ashraf Meghed, Nahil Shaker   +3 more
doaj   +1 more source

An Adaptive Protection System for Sensor Networks Based on Analysis of Neighboring Nodes. [PDF]

Sensors (Basel), 2021
Gamec J, Basan E, Basan A, Nekrasov A, Fidge C, Sushkin N.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Immunogenicity mechanism of mRNA vaccines and their limitations in promoting adaptive protection against SARS-CoV-2. [PDF]

PeerJ, 2022
Salleh MZ, Norazmi MN, Deris ZZ.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Adaptive Social Protection: A Systematic Literature Review and Research Agenda

Policy & Governance Review
Adaptive social protection represents a novel form of approach that is more holistic in addressing issues related to disasters associated with climate change and social shifts. Adaptive social protection has resurfaced social protection as a new approach
Ita Prihantika, Tia Panca Rahmadhani, Nana Mulyana   +2 more
doaj   +1 more source

Adaptive protection coordination scheme in microgrids using directional over-current relays with non-standard characteristics. [PDF]

Heliyon, 2021
Saldarriaga-Zuluaga SD, López-Lezama JM, Muñoz-Galeano N.   +2 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Review: Development of a Microdose Model for Analysis of Adaptive Response and Bystander Dose Response Behavior

Dose-Response, 2008
Prior work has provided incremental phases to a microdosimetry modeling program to describe the dose response behavior of the radio-protective adaptive response effect.
Bobby E. Leonard
doaj   +1 more source