Results 41 to 50 of about 10,328 (262)

Adaptive Forwarding and Routing of Named Data Networking A Survey

Buletin Pos dan Telekomunikasi: Media Komunikasi Ilmiah, 2023
In recent years, Named Data Networking (NDN) has been one of the future internet network architectures by proposing it as a substitute for existing IP networks. NDN assigns addresses/names to data or content, whereas IP assigns addresses to devices.
Ade Aditya Ramadha, Leanna Vidya Yovita, Tody Ariefianto Wibowo, Ilmi Aulia Assyifatunisa   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

RSU-Assisted Traffic-Aware Routing Based on Reinforcement Learning for Urban Vanets

IEEE Access, 2020
In urban vehicular ad hoc networks (VANETs), the high mobility of vehicles along street roads poses daunting challenges to routing protocols and has a great impact on network performance.
Jinqiao Wu, Min Fang, Haikun Li, Xiao Li
doaj   +1 more source

A framework for adaptive routing in multicomputer networks [PDF]

ACM SIGARCH Computer Architecture News, 1989
Message-passing concurrent computers, also known as multicomputers, such as the Caltech Cosmic Cube [47] and its commercial descendents, consist of many computing nodes that interact with each other by sending and receiving messages over communication channels between the nodes.
Ngai, John Y., Seitz, Charles L.
openaire   +3 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effects of DIF in MST routing in ILSAs

Large-scale Assessments in Education, 2023
The advance and access to technology have allowed for the implementation of adaptive testing in international large-scale assessments (ILSAs). Multistage testing (MST) in ILSAs offers opportunities and advantages compared to linear testing. However, when
Montserrat Valdivia Medinaceli, Leslie Rutkowski, Dubravka Svetina Valdivia, David Rutkowski   +3 more
doaj   +1 more source

Robust Adaptive Routing Under Uncertainty [PDF]

Operations Research, 2018
We consider the problem of finding an optimal history-dependent routing strategy on a directed graph weighted by stochastic arc costs when the objective is to minimize the risk of spending more than a prescribed budget. To help mitigate the impact of the lack of information on the arc cost probability distributions, we introduce a robust counterpart ...
Arthur Flajolet, Sebastien Blandin, Patrick Jaillet   +2 more
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source