Results 201 to 210 of about 12,788,874 (304)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Enhancing nanopore adaptive sampling for PromethION using readfish at scale. [PDF]

Genome Res
Munro R, Payne A, Holmes N, Moore C, Cahyani I, Loose M.   +5 more
europepmc   +1 more source

LAST: Latent Space-Assisted Adaptive Sampling for Protein Trajectories. [PDF]

J Chem Inf Model, 2023
Tian H, Jiang X, Xiao S, La Force H, Larson EC, Tao P.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Adaptive sampling with Oxford Nanopore offers a simple way to improve the efficiency of plant metagenomic studies. [PDF]

New Phytol
Verhoeven JTP, Malwe AS, Roussel N, Nielsen IB, Mak SST, Nielsen TK, Barnes CJ.   +6 more
europepmc   +1 more source

Metagenomic surveillance for bacterial tick-borne pathogens using nanopore adaptive sampling. [PDF]

Sci Rep, 2023
Kipp EJ, Lindsey LL, Khoo B, Faulk C, Oliver JD, Larsen PA.   +5 more
europepmc   +1 more source

Adaptive distance sampling

, 2002
We investigate mechanisms to improve efficiency for line and point transect surveys of clustered populations by combining the distance methods with adaptive sampling. In adaptive sampling, survey effort is increased when areas of high animal density are located, thereby increasing the number of observations.
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Comparative evaluation of Oxford Nanopore Technologies' adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling. [PDF]

Front Pharmacol
Deserranno K, Tilleman L, Deforce D, Van Nieuwerburgh F.   +3 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source