Results 141 to 150 of about 3,765,780 (344)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Enhancing Physical Fitness in Primary School Children Through Inclusive Sports Activities
Children(1) Background: The aim of this study is to investigate whether the application of adaptive sports programs, initially designed for children with disabilities, can have a positive effect on physical fitness and body composition in healthy primary school ...
Nikola Utvić +13 more
doaj +1 more source
Effects of adaptive-tempo music-based RAS for Parkinson’s disease patients [PDF]
, 2017 The use of Rhythmic Auditory Stimulation (RAS) is a potential method to help Parkinson Patients improve their gait characteristics. By providing auditory stimuli such as a metronome or music, gait impairments, which characterize the illness, tend to ...
Blomme, Jana +9 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Слобожанський науково-спортивний вісникBackground and Study Aim. Wheelchair basketball is a leading tool for promoting social rehabilitation and integration for individuals with disabilities.
Maksym Mishyn +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Frontiers in Sports and Active LivingIntroductionThis case report aimed to examine the effects of long-haul eastward transmeridian travel on neuromuscular performance, subjective well-being, and internal training load in a World-class female Paralympic shot-putter preparing for the Paris ...
Exal Garcia-Carrillo +17 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source