Results 141 to 150 of about 3,509,514 (324)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Enhancing Physical Fitness in Primary School Children Through Inclusive Sports Activities

Children
(1) Background: The aim of this study is to investigate whether the application of adaptive sports programs, initially designed for children with disabilities, can have a positive effect on physical fitness and body composition in healthy primary school ...
Nikola Utvić, Lidija Marković, Radenko Arsenijević, Nikola Aksović, Bojan Bjelica, Stanimir Stojljković, Saša Bubanj, Gabriela Raveica, Daniel-Lucian Dobreci, Nicolae-Lucian Voinea, Vasile-Cătălin Ciocan, Mihaela Anghel, Bogdan-Alexandru Antohe, Tatiana Dobrescu   +13 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An athletic approach to studying perception-action integration: Does sport-specific training, and the impact of injury, influence how individuals visually guide navigation? [PDF]

, 2015
The objective of this thesis was to investigate perception-action integration capabilities of individuals during a choice navigation task. This task assessed navigation strategies in open space while individuals avoided colliding with two vertical ...
Baker, Carmen, Campos, Jennifer, Ph.D, Cinelli, Michael E, Ph.D.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Formation of wheelchair handling technique in players with disabilities by means of preparatory exercises

Слобожанський науково-спортивний вісник
Background and Study Aim. Wheelchair basketball is a leading tool for promoting social rehabilitation and integration for individuals with disabilities.
Maksym Mishyn, Oleg Kamaiev, Tatiana Skaliy, Michał Słomiński   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Case Report: Jet lag and travel fatigue effects on performance in a world-class paralympic shot-putter after eastward long-haul transmeridian travel

Frontiers in Sports and Active Living
IntroductionThis case report aimed to examine the effects of long-haul eastward transmeridian travel on neuromuscular performance, subjective well-being, and internal training load in a World-class female Paralympic shot-putter preparing for the Paris ...
Exal Garcia-Carrillo, Exal Garcia-Carrillo, Rohit K. Thapa, Felipe Hermosilla-Palma, Miguel Alarcón-Rivera, Claudio Farías-Valenzuela, Jairo Azócar-Gallardo, Jairo Azócar-Gallardo, Rodrigo Yáñez-Sepúlveda, Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Antonio Castillo-Paredes, Julio Calleja-González, Lawrence W. Judge, Lawrence W. Judge, Héctor Fuentes-Barría, Héctor Fuentes-Barría, Júlio B. Mello   +17 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source