Results 91 to 100 of about 363,197 (269)

Enhancing test quality in Lesotho Basic Education through Classical Test and Item Response Theory Analyses

Journal of Computer Adaptive Testing in Africa
  This study developed and psychometrically evaluated a Grade 6 mathematics test for Lesotho’s Cambridge curriculum using Classical Test Theory (CTT) and Item Response Theory (IRT). A quantitative psychometric design involving 200 learners from Cambridge
Lefa Clement Thamae
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evaluating Student Readiness for Computer-Based and AdaptiveAssessment in Engineering Education in Nigeria

Journal of Computer Adaptive Testing in Africa
The rapid integration of digital technologies in higher education has transformed assessment practices, with computer-based and adaptive assessment systems gaining increasing attention as viable alternatives to traditional methods.
Akinola ayokunle
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Adaptive Literacy Assessment in Education

Journal of Computer Adaptive Testing in Africa
This systematic review synthesises current evidence on adaptive testing models used in literacy assessment within educational frameworks. The review was motivated by the limitations of traditional fixed-form literacy assessments, which often fail to ...
Sukurat Olamide Oyedokun, Celeste Combrinck   +1 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Q-Learning-Based Dumbo Octopus Algorithm for Parameter Tuning of Fractional-Order PID Controller for AVR Systems

Mathematics
The tuning of fractional-order proportional-integral-derivative (FOPID) controllers for automatic voltage regulator (AVR) systems presents a complex challenge, necessitating the solution of real-order integral and differential equations.
Yuanyuan Li, Lei Ni, Geng Wang, Sumeet S. Aphale, Lanqiang Zhang   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Awareness of Digital Footprint among Undergraduates in a Nigerian University

Journal of Computer Adaptive Testing in Africa
Information and communication technologies (ICTs) have become ubiquitous in modern society, and their use has given rise to the concept of digital footprint.
Olawale Sunday Koledafe
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source