Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes [PDF]
, 2015 BACKGROUND - : Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these ...
Chen, B.H. +16 more
core +1 more source
Avian Research, 2023 Island ecosystems, serving as natural laboratories, facilitate geographical isolation, ecological specialization, and species divergence. The Sichuan Basin, surrounded by mountain ranges, represents a typical continental island due to its marked ...
Lu Wang +5 more
doaj
Epigenetic Programming of Physiological Functions by a Prenatal Stressor and Genetic Parameters of Temperament in Cattle [PDF]
, 2020 This project consisted of two main objectives. Objective 1 assessed the influences of prenatal stress on 1) postnatal physiological functions and 2) the postnatal presence and prevalence of epigenetic differences, specifically degree of DNA methylation ...
Littlejohn, Brittni Paige
core
Cyclic AMP signalling pathways in the regulation of uterine relaxation [PDF]
, 2007 Studying the mechanism(s) of uterine relaxation is important and will be helpful in the prevention of obstetric difficulties such as preterm labour, which remains a major cause of perinatal mortality and morbidity.
A Belmonte +63 more
core +2 more sources
ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]
, 2018 Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core +1 more source
Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity [PDF]
, 2015 Background Genetic and epigenetic variability contributes to the susceptibility and pathogenesis of autoimmune diseases. T cells play an important role in several autoimmune conditions, including lupus, which is more common and more ...
Coit, Patrick +5 more
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Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring [PDF]
, 2010 Background: Populations of East Africa including Sudan, exhibit some of the highest indices of genetic diversity in the continent and worldwide. The current study aims to address the possible impact of population structure and population stratification ...
Eid, Nahid A +6 more
core +3 more sources
Cell-Type Specific Translational Profiling in Huntington\u27s Disease Mouse Models [PDF]
, 2011 Medium spiny neurons (MSNs) are among the most vulnerable cell populations in Huntington’s Disease (HD). Within this population, striatopallidal MSNs are more vulnerable than striatonigral MSNs, which may explain the typical progression in HD of chorea
Fenster, Robert J.
core +1 more source
Journal of Clinical Investigation, 2018 Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each other’s expression by sponging miRs. Here,
Xiaochao Tan +18 more
semanticscholar +1 more source
Screening of feature genes in distinguishing different types of breast cancer using support vector machine [PDF]
, 2015 OBJECTIVE: To screen the feature genes in estrogen receptor-positive (ER+) breast cancer in comparison with estrogen receptor-negative (ER−) breast cancer.
Qi Wang, Xudong Liu
core +2 more sources