Genome-wide dissection of microRNA functions and cotargeting networks using gene-set signatures [PDF]
, 2010 MicroRNAs are emerging as important regulators of diverse biological processes and pathologies in animals and plants. Though hundreds of human microRNAs are known, only a few have known functions.
Alexander van Oudenaarden +81 more
core +1 more source
Physiological responses to a changing winter climate in an early spring‐breeding amphibian
Ecology and Evolution, Volume 14, Issue 7, July 2024.Climate change is swiftly altering environmental winter conditions, leading to significant ecological impacts such as phenological shifts in many species. Our study points for the first time to the complex physiological challenges that amphibians face as a result of changing thermal conditions due to winter climate change.
Robin Schmidt +6 more
wiley +1 more source
Coxiella burnetii and Leishmania Mexicana Residing Within Similar Parasitophorous Vacuoles Elicit Disparate Host Responses [PDF]
, 2015 Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes. Leishmania mexicana, a eukaryote, has also independently evolved to live in a morphologically similar PV.
Cambronne, Eric D. +7 more
core +1 more source
Genomic Counter-Stress Changes Induced by the Relaxation Response [PDF]
, 2013 Background: Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced ...
Benson, Herbert +7 more
core +1 more source
Adenylyl cyclase 2 expression and function in neurological diseases
CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Marsilla Gray, Kevin R. Nash, Yao Yao
wiley +1 more source
Chronic Diseases and Translational Medicine, Volume 10, Issue 2, Page 118-129, June 2024.Differential expression genes in single‐cell transcriptomic sequencing study. (A) Uniform Manifold Approximation and Projection (UMAP) visualization showcasing distinct immune cell types among six cases and seven controls. (B) Volcano plot displaying differential expression genes between aortic dissection patients and controls.
Huan Zhang +6 more
wiley +1 more source
High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents [PDF]
, 2017 Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to hypoglycemia explain the frequency of hypoglycemia occurrence in T1D.
Ashford, Michael L. J. +4 more
core +3 more sources
Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth [PDF]
, 2016 Objective: To test several key glucocorticoid genes that are enhanced in lung development for associations with respiratory distress syndrome (RDS) after antenatal corticosteroid use.
Flockhart, David A. +7 more
core +1 more source
Statistical data mining for symbol associations in genomic databases
, 2013 A methodology is proposed to automatically detect significant symbol associations in genomic databases. A new statistical test is proposed to assess the significance of a group of symbols when found in several genesets of a given database.
Fournié, Jean-Jacques +2 more
core +3 more sources