Results 141 to 150 of about 2,548 (156)
European Heart Journal, 2019 Abstract Background/Introduction The clinical benefits of the cholesterol ester transfer protein (CETP) inhibitor dalcetrapib are dependent on the ADCY9 gene, which encodes adenylate cyclase (AC) type 9 (AC9).
Yohann Rautureau +11 more
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American Journal of Medical Genetics, 2001 AbstractChromosome 16p13 has been shown to display modest linkage signals for mood disorders in a number of studies. An interesting candidate gene in this region is the adenylate cyclase (AC) type 9 gene (ADCY9). ACs are critical in neuronal signaling, and perturbation of brain AC activity has been reported in mood disorder postmortem brains.
Tomoko Toyota +7 more
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Journal of Cardiovascular Pharmacology, 2021 Abstract: Atherosclerosis has been effectively avoided with many therapies that lower low-density lipoprotein cholesterol. However, significant cardiovascular burden remains. The effect of raising high-density lipoprotein (HDL) has been confounded by other factors (such as lowering triglycerides or LDL) and unsuccessful when attempting to ...
Donald M. Black +3 more
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Towards precision secondary prevention: pharmacogenetic insights from the dalcetrapib–ADCY9 pathway
European Journal of Preventive CardiologyAmal Aïdoud +2 more
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Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2022
To study the association of the single nucleotide polymorphisms (SNPs) of the adenylyl cyclase IX (ADCY9) gene at rs1967309, rs2230739, rs2601814, rs2601825, rs2601796, and rs2283497 loci and gene-environment interaction with childhood bronchial asthma (asthma for short).A total of 123 children with asthma who attended the hospital from March 2019 to ...
Jing-Jing, Jia +6 more
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To study the association of the single nucleotide polymorphisms (SNPs) of the adenylyl cyclase IX (ADCY9) gene at rs1967309, rs2230739, rs2601814, rs2601825, rs2601796, and rs2283497 loci and gene-environment interaction with childhood bronchial asthma (asthma for short).A total of 123 children with asthma who attended the hospital from March 2019 to ...
Jing-Jing, Jia +6 more
openaire +1 more source
Journal of clinical pharmacy and therapeutics, 2011
Inhaled combination therapy composing of long-acting β2-agonist and corticosteroid has been widely applied in the management of asthma, but observed treatment responses vary. The aim of this study was to evaluate the pharmacogenetic effect of the adenylyl cyclase type 9 (ADCY9) gene polymorphism on combination therapy.Eighty-six mild to moderate Korean
S H, Kim +4 more
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Inhaled combination therapy composing of long-acting β2-agonist and corticosteroid has been widely applied in the management of asthma, but observed treatment responses vary. The aim of this study was to evaluate the pharmacogenetic effect of the adenylyl cyclase type 9 (ADCY9) gene polymorphism on combination therapy.Eighty-six mild to moderate Korean
S H, Kim +4 more
openaire +1 more source
Therapeutic targeting in breast cancer for the treatment of lymph node metastasis: ADCY9.
Metastasis is the major cause of death from cancer. Metastasis to the lymph node (“regional” metastasis) generally precedes distant metastasis, and we recently demonstrated that metastasis to the lymph nodes is a likely prerequisite for metastasis to the central nervous system (CNS) in humans with breast cancer (1-8).openaire +1 more source